Reactome | SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol

SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol

Stable Identifier

R-HSA-443997

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

NAT1 mediates norepinephrine uptake

ReviewStatus

5/5

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SLC6A2 cotransports NAd, Na+,Cl- from extracellular region to cytosol

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Noradrenaline (NAd, norepinephrine) is a neurotransmitter whose action is mediated by the noradrenaline transporter NAT1. NAT1 is a monoamine transporter that transports noradrenaline together with Na+ and Cl- from the synapse back to its vesicles for storage until later use (Gu et al., 1994). NAT1 is encoded by the human gene SLC6A2 and is expressed in the CNS and adrenal gland (Pacholczyk et al. 1991). Defects in SLC6A2 results in orthostatic intolerance (OI), which is a syndrome characterized by lightheadedness, fatigue and development of symptoms during upright standing, relieved by sitting back down again (Shannon et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
8125921	Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence Gu, H, Wall, SC, Rudnick, G	J Biol Chem	1994
10684912	Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency Shannon, JR, Flattem, NL, Jordan, J, Jacob, G, Black, BK, Biaggioni, I, Blakely, RD, Robertson, D	N Engl J Med	2000
2008212	Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter Pacholczyk, T, Blakely, RD, Amara, SG	Nature	1991