SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol

Stable Identifier
R-HSA-443997
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
NAT1 mediates norepinephrine uptake
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Noradrenaline (NAd, norepinephrine) is a neurotransmitter whose action is mediated by the noradrenaline transporter NAT1. NAT1 is a monoamine transporter that transports noradrenaline from the synapse back to its vesicles for storage until later use. NAT1 is encoded by the human gene SLC6A2 and is expressed in the CNS and adrenal gland (Pacholczyk et al. 1991). Defects in SLC6A2 results in orthostatic intolerance (OI), which is a syndrome characterized by lightheadedness, fatigue and development of symptoms during upright standing, relieved by sitting back down again (Shannon et al. 2000).

Literature References
PubMed ID Title Journal Year
2008212 Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter

Pacholczyk, T, Blakely, RD, Amara, SG

Nature 1991
10684912 Orthostatic intolerance and tachycardia associated with norepinephrine-transporter deficiency

Shannon, JR, Flattem, NL, Jordan, J, Jacob, G, Black, BK, Biaggioni, I, Blakely, RD, Robertson, D

N Engl J Med 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
norepinephrine:sodium symporter activity of SLC6A2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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