Phosphorylation of L1 by EPHB2

Stable Identifier
R-HSA-443817
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of L1 by EPHB2
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EPH kinase Cek5/EPHB2 phosphorylates tyrosine residue in the cytoplasmic domain of NgCAM/L1. The tyrosine 1229 may be the target site. EphrinB/EphB signaling enhances L1-dependent adhesion to substrates including ALCAM and extracellular matrix proteins.

Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of EPHB2 [plasma membrane]

Physical Entity
EPHB2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Phosphorylation of L1 by EPHB2 (Gallus gallus)
Authored
Garapati, P V  (2008-07-30)
Reviewed
Maness, PF  (2010-02-16)
Created
Garapati, P V  (2009-10-12)
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