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c-Src binds Raf1
Stable Identifier
R-HSA-443439
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GP1b-IX-V activation signalling (Homo sapiens)
c-Src binds Raf1 (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
c-Src binds to Raf1, the interaction involves the SH2 and SH3 domains of c-Src and requires serine phosphorylation of Raf1. Coexpression of Raf1 and c-Src in Sf9 cells results in c-Src/Raf-1 complexes, tyrosine phosphorylation of Raf-1, and stimulation of Raf-1 kinase activity. Tyr-340 and Tyr-341 were found to be the major tyrosine phosphorylation sites of Raf1 when coexpressed with activated tyrosine kinases. However, the significance of tyrosine phosphorylation under physiological conditions remains unclear, as tyrosine phosphorylation of endogenous Raf-1 following activation has been disputed and may be limited to cells of hematopoietic origin.
Literature References
PubMed ID
Title
Journal
Year
7517401
Raf-1 interacts with Fyn and Src in a non-phosphotyrosine-dependent manner
Cleghon, V
,
Morrison, DK
J Biol Chem
1994
Participants
Input
p-Y419-SRC [cytosol]
(Homo sapiens)
RAF1 [cytosol]
(Homo sapiens)
Output
Active c-Src:Raf1 [cytosol]
(Homo sapiens)
Participates
as an event of
GP1b-IX-V activation signalling (Homo sapiens)
Orthologous Events
c-Src binds Raf1 (Caenorhabditis elegans)
c-Src binds Raf1 (Canis familiaris)
c-Src binds Raf1 (Drosophila melanogaster)
c-Src binds Raf1 (Gallus gallus)
c-Src binds Raf1 (Mus musculus)
c-Src binds Raf1 (Rattus norvegicus)
Authored
Akkerman, JW (2009-09-04)
Reviewed
Kunapuli, SP (2010-06-07)
Created
Jupe, S (2009-10-06)
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