Phosphorylation of SRC-1

Stable Identifier
R-HSA-4420206
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SRC is activated in vivo and in vitro in a VEGF/SH2D2A-dependent manner. VEGF induces phosphorylation of the activating Y418 residue, located on the c-SRC kinase activation loop, but also decreases phosphorylation of the negative regulatory Y527 (Sun et al. 2012).

Literature References
PubMed ID Title Journal Year
22689825 VEGFR2 induces c-Src signaling and vascular permeability in vivo via the adaptor protein TSAd

Sun, Z, Li, X, Massena, S, Kutschera, S, Padhan, N, Gualandi, L, Sundvold-Gjerstad, V, Gustafsson, K, Choy, WW, Zang, G, Quach, M, Jansson, L, Phillipson, M, Abid, MR, Spurkland, A, Claesson-Welsh, L

J. Exp. Med. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of VEGFA dimer:p-6Y-VEGFR2 dimer:SH2D2A:SRC-1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created