Reactome | p-6Y-VEGFR2 binds SH2D2A

p-6Y-VEGFR2 binds SH2D2A

Stable Identifier

R-HSA-4420143

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Two-hybrid mapping showed that tyrosine 951 (Y951) serves as the binding site for T-cell specific adapter molecule (TSAD/ SH2 domain-containing protein 2A (SH2D2A)), also referred as VEGF-receptor-associated protein (VRAP) (Wu et al. 2000). SH2D2A mediates vasular permeability downstream of VEGFR2 by forming a complex with c-SRC (Sun et al. 2012). Site-directed mutation of Y951 to phenylalanine (Y951F) in the VEGFR2, or siRNA mediated silencing of SH2D2A expression, prevented VEGFA mediated cytoskeletal reorganisation and migration but not mitogenicity (Matsumoto et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15962004	VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis Matsumoto, T, Bohman, S, Dixelius, J, Berge, T, Dimberg, A, Magnusson, P, Wang, L, Wikner, C, Qi, JH, Wernstedt, C, Wu, J, Bruheim, S, Mugishima, H, Mukhopadhyay, D, Spurkland, A, Claesson-Welsh, L	EMBO J.	2005
10692392	VRAP is an adaptor protein that binds KDR, a receptor for vascular endothelial cell growth factor Wu, LW, Mayo, LD, Dunbar, JD, Kessler, KM, Ozes, ON, Warren, RS, Donner, DB	J. Biol. Chem.	2000