SFKs phosphorylate PLCG1

Stable Identifier
R-HSA-4420121
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SFKs phosphorylate PLCG1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activation of VEGFR2 has been shown to lead to direct binding and phosphorylation of PLC-gamma 1 (McLaughlin & Vries 2001). PLCG1 is tyrosine phosphorylated directly by VEGFR2 or through the Src kinases on four tyrosine residues, enhancing the activity of PLCG1.

Literature References
PubMed ID Title Journal Year
11600407 Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation

McLaughlin, AP, De Vries, GW

Am. J. Physiol., Cell Physiol. 2001
15879121 A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling

Serrano, CJ, Graham, L, DeBell, K, Rawat, R, Veri, MC, Bonvini, E, Rellahan, BL, Reischl, IG

J. Immunol. 2005
20807769 Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

Gresset, A, Hicks, SN, Harden, TK, Sondek, J

J. Biol. Chem. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [cytosol]
Physical Entity
SRC-1 [cytosol]
Activity
protein tyrosine kinase activity (0004713)
Orthologous Events
SFKs phosphorylate PLCG1 (Bos taurus)
SFKs phosphorylate PLCG1 (Canis familiaris)
SFKs phosphorylate PLCG1 (Danio rerio)
SFKs phosphorylate PLCG1 (Mus musculus)
SFKs phosphorylate PLCG1 (Rattus norvegicus)
SFKs phosphorylate PLCG1 (Sus scrofa)
SFKs phosphorylate PLCG1 (Xenopus tropicalis)
Authored
Garapati, P V  (2013-08-30)
Reviewed
Welsh, M  (2014-05-12)
Berger, P  (2014-05-12)
Ballmer-Hofer, K  (2014-05-12)
Created
Garapati, P V  (2013-08-30)