Reactome | SFKs phosphorylate PLCG1

SFKs phosphorylate PLCG1

Stable Identifier

R-HSA-4420121

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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Activation of VEGFR2 has been shown to lead to direct binding and phosphorylation of PLC-gamma 1 (McLaughlin & Vries 2001). PLCG1 is tyrosine phosphorylated directly by VEGFR2 or through the Src kinases on four tyrosine residues, enhancing the activity of PLCG1.

Literature References

PubMed ID	Title	Journal	Year
11600407	Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation McLaughlin, AP, De Vries, GW	Am. J. Physiol., Cell Physiol.	2001
15879121	A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling Serrano, CJ, Graham, L, DeBell, K, Rawat, R, Veri, MC, Bonvini, E, Rellahan, BL, Reischl, IG	J. Immunol.	2005
20807769	Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes Gresset, A, Hicks, SN, Harden, TK, Sondek, J	J. Biol. Chem.	2010