SFKs phosphorylate PLCG1

Stable Identifier
R-HSA-4420121
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Activation of VEGFR2 has been shown to lead to direct binding and phosphorylation of PLC-gamma 1 (McLaughlin & Vries 2001). PLCG1 is tyrosine phosphorylated directly by VEGFR2 or through the Src kinases on four tyrosine residues, enhancing the activity of PLCG1.

Literature References
PubMed ID Title Journal Year
11600407 Role of PLCgamma and Ca(2+) in VEGF- and FGF-induced choroidal endothelial cell proliferation

McLaughlin, AP, De Vries, GW

Am. J. Physiol., Cell Physiol. 2001
15879121 A new tyrosine phosphorylation site in PLC gamma 1: the role of tyrosine 775 in immune receptor signaling

Serrano, CJ, Graham, L, DeBell, K, Rawat, R, Veri, MC, Bonvini, E, Rellahan, BL, Reischl, IG

J. Immunol. 2005
20807769 Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes

Gresset, A, Hicks, SN, Harden, TK, Sondek, J

J. Biol. Chem. 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of SRC-1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created