Activation of VEGFR2 has been shown to lead to direct binding and phosphorylation of PLC-gamma 1 (McLaughlin & Vries 2001). PLCG1 is tyrosine phosphorylated directly by VEGFR2 or through the Src kinases on four tyrosine residues, enhancing the activity of PLCG1.
Reischl, IG, Graham, L, DeBell, K, Rellahan, BL, Rawat, R, Serrano, CJ, Veri, MC, Bonvini, E
McLaughlin, AP, De Vries, GW
Hicks, SN, Sondek, J, Harden, TK, Gresset, A
protein tyrosine kinase activity of SRC-1 [cytosol]
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