Reactome | Activation of NLK

Activation of NLK

Stable Identifier

R-HSA-4411402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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NLK is activated in response to WNT5A in a CAMK2- and MAP3K7- dependent manner (Ishitani et al, 1999; Ishitani et al, 2003a,b). Homodimerization is required for NLK autophosphorylation at T298 and subsequent nuclear localization; mutation of C437 abolishes dimerization, kinase activity and nuclear translocation (Ishitani et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
12556497	Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling Ishitani, T, Ninomiya-Tsuji, J, Matsumoto, K	Mol. Cell. Biol.	2003
21118996	Homodimerization of Nemo-like kinase is essential for activation and nuclear localization Ishitani, S, Inaba, K, Matsumoto, K, Ishitani, T	Mol. Biol. Cell	2011
10391247	The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF Ishitani, T, Ninomiya-Tsuji, J, Nagai, S, Nishita, M, Meneghini, M, Barker, N, Waterman, M, Bowerman, B, Clevers, HC, Shibuya, H, Matsumoto, K	Nature	1999
12482967	The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling Ishitani, T, Kishida, S, Hyodo-Miura, J, Ueno, N, Yasuda, J, Waterman, M, Shibuya, H, Moon, RT, Ninomiya-Tsuji, J, Matsumoto, K	Mol. Cell. Biol.	2003