Activation of NLK

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NLK is activated in response to WNT5A in a CAMK2- and MAP3K7- dependent manner (Ishitani et al, 1999; Ishitani et al, 2003a,b). Homodimerization is required for NLK autophosphorylation at T298 and subsequent nuclear localization; mutation of C437 abolishes dimerization, kinase activity and nuclear translocation (Ishitani et al, 2011).
Literature References
PubMed ID Title Journal Year
12556497 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling

Ishitani, T, Matsumoto, K, Ninomiya-Tsuji, J

Mol. Cell. Biol. 2003
21118996 Homodimerization of Nemo-like kinase is essential for activation and nuclear localization

Ishitani, T, Inaba, K, Matsumoto, K, Ishitani, S

Mol. Biol. Cell 2011
10391247 The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF

Shibuya, H, Barker, N, Clevers, HC, Bowerman, B, Ishitani, T, Waterman, M, Matsumoto, K, Meneghini, M, Ninomiya-Tsuji, J, Nagai, S, Nishita, M

Nature 1999
12482967 The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling

Shibuya, H, Ishitani, T, Hyodo-Miura, J, Waterman, M, Matsumoto, K, Yasuda, J, Ninomiya-Tsuji, J, Ueno, N, Moon, RT, Kishida, S

Mol. Cell. Biol. 2003
Catalyst Activity

protein serine/threonine kinase activity of NLK [cytosol]

This event is regulated
Orthologous Events
Cite Us!