Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF

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R-HSA-4411365
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Reaction [omitted]
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Homo sapiens
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The presence of a TCF/LEF:beta catenin complex at the promoter is an preliminary requirement for the activation of transcription at many WNT target genes (reviewed in Saito-Diaz et al, 2013). The ability of the TCF/LEF:beta-catenin complex to bind DNA is negatively regulated by NLK-dependent phosphorylation (Ishitani et al, 2003b). WNT targets AXIN2, DKK1, c-MYC and CCND1 all show decreased expression in A549 cells treated with shRNAs against NLK (Lv et al, 2013).

Literature References
PubMed ID Title Journal Year
23256519 The way Wnt works: Components and mechanism

Saito-Diaz, K, Chen, TW, Wang, X, Thorne, CA, Wallace, HA, Page-McCaw, A, Lee, E

Growth Factors 2013
12556497 Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling

Ishitani, T, Ninomiya-Tsuji, J, Matsumoto, K

Mol. Cell. Biol. 2003
23904219 Nemo-like kinase (NLK) inhibits the progression of NSCLC via negatively modulating Wnt signaling pathway

Lv, L, Wan, C, Chen, B, Li, M, Liu, Y, Ni, T, Yang, Y, Liu, Y, Cong, X, Xue, Q, Mao, G

J. Cell. Biochem. 2013
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