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ORAI1 [plasma membrane]
Stable Identifier
R-HSA-434672
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Calcium release-activated calcium channel protein 1, CRCM1_HUMAN, CRACM1
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet calcium homeostasis (Homo sapiens)
Elevation of cytosolic Ca2+ levels (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
STIM1 activation of CRAC (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
CRAC translocates calcium from the extracellular region to the cytosol (Homo sapiens)
CRAC channel [plasma membrane] (Homo sapiens)
ORAI dimer [plasma membrane] (Homo sapiens)
ORAI1 dimer [plasma membrane] (Homo sapiens)
ORAI1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96D31 ORAI1
Gene Names
ORAI1, CRACM1, TMEM142A
Chain
chain:1-301
Reference Genes
BioGPS Gene:84876 ORAI1
COSMIC (genes):ORAI1 ORAI1
CTD Gene:84876 ORAI1
dbSNP Gene:84876 ORAI1
ENSEMBL:ENSG00000276045 ORAI1
HGNC:25896 ORAI1
KEGG:hsa:84876 ORAI1
Monarch:84876 ORAI1
NCBI Gene:84876 ORAI1
OMIM:610277 ORAI1
UCSC:Q96D31 ORAI1
Reference Transcript
RefSeq:NM_032790.3 ORAI1
Other Identifiers
11723292_at
16758130
226531_PM_at
226531_at
3434889
3434890
3434891
3434892
3434897
3434898
3434899
3434900
3434902
46098_at
61400_i_at
7959294
A_14_P122810
A_23_P150919
A_23_P258837
GO:0002115
GO:0002250
GO:0002376
GO:0005215
GO:0005262
GO:0005515
GO:0005516
GO:0005886
GO:0007200
GO:0015279
GO:0016020
GO:0016323
GO:0032024
GO:0032991
GO:0033173
GO:0034704
GO:0042802
GO:0044853
GO:0045121
GO:0045762
GO:0048856
GO:0051924
GO:0051928
GO:0055085
GO:0061180
GO:0070509
GO:0070588
GO:0099105
GO:1990806
HMNXSV003004182
Hs.55148.0.A1_3p_at
ILMN_1724148
PH_hs_0035434
TC12000961.hg
Participates
as a component of
ORAI1 dimer [plasma membrane] (Homo sapiens)
Cross References
RefSeq
NP_116179.2
Guide to Pharmacology - Targets
2964
ENSEMBL
ENSP00000482568
,
ENST00000617316
,
ENSG00000276045
OpenTargets
ENSG00000276045
ZINC - Substances
CRCM1_HUMAN
ZINC target
Q96D31
PRO
Q96D31
GlyGen
Q96D31
PDB
4EHQ
,
2MAK
GeneCards
ORAI1
HPA
ENSG00000276045-ORAI1
Pharos - Targets
Q96D31
Orphanet
ORAI1
ZINC - Predictions - Purchasable
CRCM1_HUMAN
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13507 TRPC3
1
TRPC3(1-848) [plasma membrane]
(R-HSA-426172)
0.544
2
UniProt:P43657 LPAR6
1
LPAR6 [plasma membrane]
(R-HSA-417913)
0.527
2
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