Dissociation of CaM and CAMK2 autophosphorylation

Stable Identifier
R-HSA-4332358
Type
Reaction
Species
Homo sapiens
Compartment
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Dissociation of Ca2+/CaM from activated CAMK2 allows subsequent phosphorylations at Thr 305 and Thr 306. These phosphorylations, which occur within the CaM binding site, prevent reassociation of Ca2+/CaM (reviewed in Stratton et al, 2013).

Literature References
PubMed ID Title Journal Year
23632248 Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

Schulman, H, Stratton, MM, Kuriyan, J, Chao, LH

Curr. Opin. Struct. Biol. 2013
Participants
Participates
Catalyst Activity

protein serine/threonine kinase activity of p-T286 CAMK2:CaM [cytosol]

Orthologous Events
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