Dissociation of CaM and CAMK2 autophosphorylation

Stable Identifier
R-HSA-4332358
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Dissociation of CaM and CAMK2 autophosphorylation
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Dissociation of Ca2+/CaM from activated CAMK2 allows subsequent phosphorylations at Thr 305 and Thr 306. These phosphorylations, which occur within the CaM binding site, prevent reassociation of Ca2+/CaM (reviewed in Stratton et al, 2013).

Literature References
PubMed ID Title Journal Year
23632248 Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

Stratton, MM, Chao, LH, Schulman, H, Kuriyan, J

Curr. Opin. Struct. Biol. 2013
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of p-T286 CAMK2:CaM [cytosol]
Physical Entity
p-T286 CAMK2:CaM [cytosol]
Activity
protein serine/threonine kinase activity (0004674)
Orthologous Events
Dissociation of CaM and CAMK2 autophosphorylation (Bos taurus)
Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)
Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
Dissociation of CaM and CAMK2 autophosphorylation (Danio rerio)
Dissociation of CaM and CAMK2 autophosphorylation (Dictyostelium discoideum)
Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)
Dissociation of CaM and CAMK2 autophosphorylation (Gallus gallus)
Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)
Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)
Dissociation of CaM and CAMK2 autophosphorylation (Sus scrofa)
Dissociation of CaM and CAMK2 autophosphorylation (Xenopus tropicalis)
Authored
Rothfels, K  (2013-08-17)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-08-17)
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