Dissociation of CaM and CAMK2 autophosphorylation

Stable Identifier
R-HSA-4332358
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Dissociation of CaM and CAMK2 autophosphorylation
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Dissociation of Ca2+/CaM from activated CAMK2 allows subsequent phosphorylations at Thr 305 and Thr 306. These phosphorylations, which occur within the CaM binding site, prevent reassociation of Ca2+/CaM (reviewed in Stratton et al, 2013).
Literature References
PubMed ID Title Journal Year
23632248 Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II

Stratton, MM, Chao, LH, Schulman, H, Kuriyan, J

Curr. Opin. Struct. Biol. 2013
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-T286 CAMK2:CaM [cytosol]

Physical Entity
p-T286 CAMK2:CaM [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Dissociation of CaM and CAMK2 autophosphorylation (Caenorhabditis elegans)
Dissociation of CaM and CAMK2 autophosphorylation (Canis familiaris)
Dissociation of CaM and CAMK2 autophosphorylation (Drosophila melanogaster)
Dissociation of CaM and CAMK2 autophosphorylation (Mus musculus)
Dissociation of CaM and CAMK2 autophosphorylation (Rattus norvegicus)
Authored
Rothfels, K  (2013-08-17)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-08-17)
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