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Sodium-coupled sulphate, di- and tri-carboxylate transporters
Stable Identifier
R-HSA-433137
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Homo sapiens)
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Five human SLC13 genes encode sodium-coupled sulphate, di- and tri-carboxylate transporters located on the plasma membrane. Two transporters (NaS1 and NaS2) co-transport sulphate with sodium. The other members (NaDC1, NaDC3, and NaCT) co-transport sodium with di- and tri-carboxylates such as succinate, citrate and alpha-ketoglutarate (Pajor AM, 2006).
Literature References
PubMed ID
Title
Journal
Year
16211368
Molecular properties of the SLC13 family of dicarboxylate and sulfate transporters
Pajor, AM
Pflugers Arch
2006
Participants
Events
NaS1 co-transports sulphate and a sodium ion
(Homo sapiens)
NaS2 co-transports sulphate and two sodium ions
(Homo sapiens)
NaDC1 co-transports dicarboxylic acids and a sodium ion
(Homo sapiens)
NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion
(Homo sapiens)
NACT co-transports trivalent citrate and a sodium ion
(Homo sapiens)
Participates
as an event of
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Orthologous Events
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Bos taurus)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Caenorhabditis elegans)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Canis familiaris)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Danio rerio)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Drosophila melanogaster)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Gallus gallus)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Mus musculus)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Rattus norvegicus)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Sus scrofa)
Sodium-coupled sulphate, di- and tri-carboxylate transporters (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000054
Authored
Jassal, B (2009-08-21)
Reviewed
He, L (2009-11-12)
Created
Jassal, B (2009-08-21)
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