Reactome | NaS2 co-transports sulphate and two sodium ions

NaS2 co-transports sulphate and two sodium ions

Stable Identifier

R-HSA-433099

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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NaS2 co-transports sulphate and two sodium ions

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The human gene SLC13A4 encodes a sodium/sulphate co-transporter NaS2 (Girard JP et al, 1999). NaS2 is highly expressed in placenta and testis, mainly in high endothelial venules. Kinetic experiments suggest two sodium ions co-transported for every sulphate ion (Markovich D et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
15607730	Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4) Kunzelmann, K, Regeer, RR, Markovich, D, Dawson, PA	Biochem Biophys Res Commun	2005
10535998	Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules Girard, JP, Brandtzaeg, P, Baekkevold, ES, Feliu, J, Amalric, F	Proc Natl Acad Sci U S A	1999