NaS2 co-transports sulphate and two sodium ions

Stable Identifier
R-HSA-433099
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The human gene SLC13A4 encodes a sodium/sulphate co-transporter NaS2 (Girard JP et al, 1999). NaS2 is highly expressed in placenta and testis, mainly in high endothelial venules. Kinetic experiments suggest two sodium ions co-transported for every sulphate ion (Markovich D et al, 2005).

Literature References
PubMed ID Title Journal Year
10535998 Molecular cloning and functional analysis of SUT-1, a sulfate transporter from human high endothelial venules

Girard, JP, Baekkevold, ES, Feliu, J, Brandtzaeg, P, Amalric, F

Proc Natl Acad Sci U S A 1999
15607730 Functional characterization and genomic organization of the human Na(+)-sulfate cotransporter hNaS2 gene (SLC13A4)

Markovich, D, Regeer, RR, Kunzelmann, K, Dawson, PA

Biochem Biophys Res Commun 2005
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Catalyst Activity
Title
sodium:sulfate symporter activity of SLC13A4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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