TP53 binds the PMAIP1 (NOXA) promoter

Stable Identifier
R-HSA-4331331
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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TP53 (p53) binds the promoter of the PMAIP1 (NOXA) gene to induce PMAIP1 transcription (Oda et al. 2000, Li et al. 2004). TP53 likely associates with the PMAIP1 promoter as part of the complex with ASPP proteins PPP1R13B (ASPP1) or TP53BP2 (ASPP2) (Wang et al. 2012, Wilson et al. 2013).

Literature References
PubMed ID Title Journal Year
15126337 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

Li, CQ, Robles, AI, Hanigan, CL, Hofseth, LJ, Trudel, LJ, Harris, CC, Wogan, GN

Cancer Res 2004
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A

J. Neurosci. 2013
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Oda, E, Ohki, R, Murasawa, H, Nemoto, J, Shibue, T, Yamashita, T, Tokino, T, Taniguchi, T, Tanaka, N

Science 2000
22766503 iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes

Wang, L, Xing, H, Tian, Z, Peng, L, Li, Y, Tang, K, Rao, Q, Wang, M, Wang, J

Biochem. Biophys. Res. Commun. 2012
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