Activation of NOXA and translocation to mitochondria

Stable Identifier
R-HSA-111448
Type
Pathway
Species
Homo sapiens
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NOXA is transactivated in a p53-dependent manner and by E2F1. Activated NOXA is translocated to mitochondria.

Literature References
PubMed ID Title Journal Year
15126337 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

Li, CQ, Robles, AI, Hanigan, CL, Hofseth, LJ, Trudel, LJ, Harris, CC, Wogan, GN

Cancer Res 2004
14684737 Up-regulation of Bcl-2 homology 3 (BH3)-only proteins by E2F1 mediates apoptosis

Hershko, T, Ginsberg, D

J Biol Chem 2004
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Orthologous Events
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