FGR binds and phosphorylates LRP8

Stable Identifier
R-HSA-432129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Tyrosine phosphorylation of LDL:LRP8 is mediated by the Src-family kinase FGR, based on a correlation of increased LRP8 phosphorylation on LDL stimulation of platelets, and a transient increased co-precipitation of FGR with LRP8 upon LDL stimulation.

Literature References
PubMed ID Title Journal Year
15459198 Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK

Korporaal, SJ, Relou, IA, van Eck, M, Strasser, V, Bezemer, M, Gorter, G, van Berkel, TJ, Nimpf, J, Akkerman, JW, Lenting, PJ

J Biol Chem 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of LDL:LRP8:FGR [plasma membrane]
Physical Entity
Activity
Orthologous Events
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