Reactome | Platelet sensitization by LDL

Platelet sensitization by LDL

Stable Identifier

R-HSA-432142

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

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Physiological concentrations (1g/L) of Low density lipoprotein (LDL) enhance platelet aggregation responses initiated by thrombin, collagen, and ADP. This enhancement involves the rapid phosphorylation of p38 mitogen-activated protein kinase (p38MAPK) at Thr180 and Tyr182. The receptor for LDL is ApoER2, a splice variant of the classical ApoE receptor. ApoER2 stimulation leads to association of the Src family kinase Fgr which is probably responsible for subsequent phosphorylation of p38MAPK. This stimulation is transient because LDL also increases the activity of PECAM-1, which stimulates phosphatases that dephosphorylate p38MAPK.

Literature References

PubMed ID	Title	Journal	Year
15459198	Binding of low density lipoprotein to platelet apolipoprotein E receptor 2' results in phosphorylation of p38MAPK Korporaal, SJ, Relou, IA, van Eck, M, Strasser, V, Bezemer, M, Gorter, G, van Berkel, TJ, Nimpf, J, Akkerman, JW, Lenting, PJ	J Biol Chem	2004
12775720	Platelet endothelial cell adhesion molecule-1 (PECAM-1) inhibits low density lipoprotein-induced signaling in platelets Relou, IA, Gorter, G, Ferreira, IA, van Rijn, HJ, Akkerman, JW	J Biol Chem	2003
12038793	Platelet activation by the apoB/E receptor-binding domain of LDL Relou, AM, Gorter, G, van Rijn, HJ, Akkerman, JW	Thromb Haemost	2002