Reactome | GP1b-IX-V binds filamin

GP1b-IX-V binds filamin

Stable Identifier

R-HSA-430096

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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GP1b-IX-V interacts with filamin-1; within the cytoplasmic domain of GP1b alpha amino acids 557-568 and 569-579 are critical for this association. GPIb-filamin-1 association links the receptor complex to the membrane skeleton and has been proposed to regulate the ability of GPIb-IX-V to adhere to vWf under conditions of high shear.

Literature References

PubMed ID	Title	Journal	Year
3155520	On the association of glycoprotein Ib and actin-binding protein in human platelets Okita, JR, Pidard, D, Newman, PJ, Montgomery, RR, Kunicki, TJ	J Cell Biol	1985
11700320	Interaction between platelet glycoprotein Ibalpha and filamin-1 is essential for glycoprotein Ib/IX receptor anchorage at high shear Williamson, D, Pikovski, I, Cranmer, SL, Mangin, P, Mistry, N, Domagala, T, Chehab, S, Lanza, F, Salem, HH, Jackson, SP	J Biol Chem	2002