GP1b-IX-V interacts with filamin-1; within the cytoplasmic domain of GP1b alpha amino acids 557-568 and 569-579 are critical for this association. GPIb-filamin-1 association links the receptor complex to the membrane skeleton and has been proposed to regulate the ability of GPIb-IX-V to adhere to vWf under conditions of high shear.
Pidard, D, Montgomery, RR, Okita, JR, Newman, PJ, Kunicki, TJ
Domagala, T, Mistry, N, Lanza, F, Cranmer, SL, Jackson, SP, Pikovski, I, Chehab, S, Salem, HH, Mangin, P, Williamson, D
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