Activation of RAC1 by SOS

Stable Identifier
R-HSA-428535
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

SOS (SOS1 or SOS2), bound to Dock orholog NCK (NCK1 or NCK2), has a Rac GEF activity and activates RAC1. Son of sevenless (SOS) is a dual specificity guanine nucleotide exchange factor (GEF) that regulates both Ras and Rho family GTPases. The Ras and Rac-GEF activities of Sos can be uncoupled during ROBO-mediated axon repulsion; SOS axon guidance function depends on its Rac-GEF activity, but not its Ras-GEF activity (Yang and Bashaw 2006).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
Rac guanyl-nucleotide exchange factor activity of SLIT2:ROBO1:NCK:SOS [plasma membrane]
Physical Entity
Activity
Inferred From
Authored
Reviewed
Created
Cite Us!