Reactome | Proton-coupled histidine and di-peptide cotransport

Proton-coupled histidine and di-peptide cotransport

Stable Identifier

R-HSA-428007

Type

Reaction [transition]

Species

Homo sapiens

Compartment

lysosomal membrane

ReviewStatus

5/5

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Proton-coupled histidine and di-peptide cotransport

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A bioinformatics approach identified two further human transporters, PHT1 and PHT2 (Botka CW et al, 2000). These two transporters may be located on the lysosomal membrane for the proton-coupled export of histidine and di-peptides from lysosomal protein degradation.

Literature References

PubMed ID	Title	Journal	Year
11741232	Human proton/oligopeptide transporter (POT) genes: identification of putative human genes using bioinformatics Higaka, K, Wittig, TW, Nielsen, CU, Sadee, W, Amidon, GL, Graul, RC, Botka, CW	AAPS PharmSci	2000