Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)

Stable Identifier
Reaction [binding]
Homo sapiens
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RRP8 (Nucleomethylin, NML), SIRT1, and SUV39H1 form the energy-dependent Nucleolar Silencing Complex (eNoSC) at inactive rRNA genes (Murayama et al. 2008). RRP8 is constitutively located in the nucleolus (Yang et al. 2013), binds histone H3 dimethylated at lysine-9 (Murayama et al. 2008) and appears to recruit SIRT1 from the nucleoplasm to the nucleolus (Yang et al. 2013). The eNoSC binds chromatin throughout the rRNA transcription unit. SIRT1 may deacetylate and, hence, activate SUV39H1 but this has not yet been shown at rDNA. Abrogation of any member of eNoSC interferes with binding of the other members of the complex. The eNoSC complex appears to cause spreading of heterochromatin at rDNA.

Literature References
PubMed ID Title Journal Year
23897426 Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability

Zheng, H, Chen, L, Chen, J, Seto, E, Song, T, Yang, L, Kabra, N, Koomen, J

Mol. Cell. Biol. 2013
18485871 Epigenetic control of rDNA loci in response to intracellular energy status

Fujimura, A, Murayama, A, Minami, H, Nagata, K, Kuroda, T, Kimura, K, Oie, S, Ohmori, K, Yasuzawa-Tanaka, K, Daitoku, H, Yanagisawa, J, Fukamizu, A, Okuwaki, M, Shimizu, T

Cell 2008
This event is regulated