Reactome | Na+/H+ exchanger transport (at cell membrane)

Na+/H+ exchanger transport (at cell membrane)

Stable Identifier

R-HSA-425994

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Na+/H+ exchanger transport (at cell membrane)

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NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.

Literature References

PubMed ID	Title	Journal	Year
10444453	Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2 Malakooti, J, Dahdal, RY, Schmidt, L, Layden, TJ, Dudeja, PK, Ramaswamy, K	Am J Physiol	1999
9933641	Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain Baird, NR, Orlowski, J, Szabó, EZ, Zaun, HC, Schultheis, PJ, Menon, AG, Shull, GE	J Biol Chem	1999
7631746	Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3 Brant, SR, Yun, CH, Donowitz, M, Tse, CM	Am J Physiol	1995
2536298	Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter Sardet, C, Franchi, A, Pouysségur, J	Cell	1989