NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.
Baird, NR, Orlowski, J, Szabó, EZ, Zaun, HC, Schultheis, PJ, Menon, AG, Shull, GE
Malakooti, J, Dahdal, RY, Schmidt, L, Layden, TJ, Dudeja, PK, Ramaswamy, K
Brant, SR, Yun, CH, Donowitz, M, Tse, CM
Sardet, C, Franchi, A, Pouysségur, J
sodium:proton antiporter activity of SLC9A1-5 [plasma membrane]
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