Na+/H+ exchanger transport (at cell membrane)

Stable Identifier
Reaction [transition]
Homo sapiens
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NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.

Literature References
PubMed ID Title Journal Year
10444453 Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2

Schmidt, L, Ramaswamy, K, Layden, TJ, Malakooti, J, Dahdal, RY, Dudeja, PK

Am J Physiol 1999
9933641 Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain

Schultheis, PJ, Baird, NR, Menon, AG, Zaun, HC, Shull, GE, Orlowski, J, Szabó, EZ

J Biol Chem 1999
7631746 Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3

Yun, CH, Brant, SR, Tse, CM, Donowitz, M

Am J Physiol 1995
2536298 Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter

Pouysségur, J, Franchi, A, Sardet, C

Cell 1989
Catalyst Activity

sodium:proton antiporter activity of SLC9A1-5 [plasma membrane]

Orthologous Events
Cross References
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