NHE1 (SLC9A1) is present in most cells and is the most extensively characterized member of this family (Sardet C et al, 1989). NHE2-4 (SLC9A2-4) (Malakooti J et al, 1999; Brant SR et al, 1995) are expressed mainly in the kidney and GI tract. NHE5 (SLC9A5) (Baird NR et al, 1999) is highly expressed in neuronal-enriched areas of the CNS.
Schmidt, L, Ramaswamy, K, Layden, TJ, Malakooti, J, Dahdal, RY, Dudeja, PK
Schultheis, PJ, Baird, NR, Menon, AG, Zaun, HC, Shull, GE, Orlowski, J, Szabó, EZ
Yun, CH, Brant, SR, Tse, CM, Donowitz, M
Pouysségur, J, Franchi, A, Sardet, C
sodium:proton antiporter activity of SLC9A1-5 [plasma membrane]
© 2023 Reactome