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GPRC6A [plasma membrane]
Stable Identifier
R-HSA-420726
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G-protein coupled receptor family C group 6 member A, GPC6A_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
GPRC6A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T6X5 GPRC6A
Gene Names
GPRC6A
Chain
signal peptide:1-18, chain:19-926
Reference Genes
BioGPS Gene:222545 GPRC6A
COSMIC (genes):GPRC6A GPRC6A
CTD Gene:222545 GPRC6A
dbSNP Gene:222545 GPRC6A
ENSEMBL:ENSG00000173612 GPRC6A
HGNC:18510 GPRC6A
KEGG:hsa:222545 GPRC6A
Monarch:222545 GPRC6A
NCBI Gene:222545 GPRC6A
OMIM:613572 GPRC6A
UCSC:Q5T6X5 GPRC6A
Reference Transcript
RefSeq:NM_148963.3 GPRC6A
RefSeq:NM_001286354.1 GPRC6A
RefSeq:NM_001286355.1 GPRC6A
Other Identifiers
11740664_a_at
1552775_PM_at
1552775_at
17022987
222545
2971205
2971206
2971207
2971208
2971212
2971216
2971217
2971218
2971219
2971221
2971222
8129125
A_23_P81683
GE550437
GO:0004930
GO:0005886
GO:0007186
GO:0016020
GO:0043200
GO:0060089
GO:2000224
HMNXSV003009247
Hs2.266745.1.S1_3p_at
ILMN_1732807
PH_hs_0013686
TC06002053.hg
Participates
as an input of
GPRC6A can bind L-alpha amino acids and calcium (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
GPRC6A receptor:GPRC6A ligands [plasma membrane] (Homo sapiens)
Inferred To
gprc6a [plasma membrane]
(Danio rerio)
gprc6a.2 [plasma membrane]
(Xenopus tropicalis)
Gprc6a [plasma membrane]
(Mus musculus)
Gprc6a [plasma membrane]
(Rattus norvegicus)
GPRC6A [plasma membrane]
(Canis familiaris)
GPRC6A [plasma membrane]
(Gallus gallus)
GPRC6A [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_683766.2
,
NP_001273284.1
,
NP_001273283.1
Guide to Pharmacology - Targets
55
ENSEMBL
ENST00000310357
,
ENST00000530250
,
ENST00000368549
,
ENSP00000309493
,
ENSP00000357537
,
ENSP00000433465
OpenTargets
ENSG00000173612
HPA
ENSG00000173612-GPRC6A
PRO
Q5T6X5
Pharos - Targets
Q5T6X5
GlyGen
Q5T6X5
HMDB Protein
HMDBP07715
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