Reactome | GPRC6A can bind L-alpha amino acids and calcium

GPRC6A can bind L-alpha amino acids and calcium

Stable Identifier

R-HSA-420739

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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GPRC6A can bind L-alpha amino acids and calcium

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G-protein coupled receptor family C group 6 member A (GPRC6A, GPCR33) (Wellendorph P and Brauner-Osborne H, 2004) is a receptor that functions as a sensor for both L-amino acids and extracellular concentration of calcium ions. GPRC6A is a promiscuous L-alpha-amino acid receptor but has preference for the basic amino-acids L-Arg, L-Lys and L-ornithine (Wellendorph P et al, 2005). The effects of this receptor are mediated by coupling to the G protein alpha q/11 subunit, which activates a phosphatidylinositol-calcium second messenger system.

Literature References

PubMed ID	Title	Journal	Year
15194188	Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor Wellendorph, P, Brauner-Osborne, H	Gene	2004
15576628	Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids Wellendorph, P, Hansen, KB, Balsgaard, A, Greenwood, JR, Egebjerg, J, Brauner-Osborne, H	Mol Pharmacol	2005