GPRC6A can bind L-alpha amino acids and calcium

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

G-protein coupled receptor family C group 6 member A (GPRC6A, GPCR33) (Wellendorph P and Brauner-Osborne H, 2004) is a receptor that functions as a sensor for both L-amino acids and extracellular concentration of calcium ions. GPRC6A is a promiscuous L-alpha-amino acid receptor but has preference for the basic amino-acids L-Arg, L-Lys and L-ornithine (Wellendorph P et al, 2005). The effects of this receptor are mediated by coupling to the G protein alpha q/11 subunit, which activates a phosphatidylinositol-calcium second messenger system.

Literature References
PubMed ID Title Journal Year
15194188 Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor

Wellendorph, P, Brauner-Osborne, H

Gene 2004
15576628 Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids

Greenwood, JR, Wellendorph, P, Egebjerg, J, Balsgaard, A, Hansen, KB, Brauner-Osborne, H

Mol Pharmacol 2005
Orthologous Events
Cite Us!