GIP receptor binds gastric inhibitory peptide

Stable Identifier
Reaction [binding]
Homo sapiens
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Gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic peptide) (Moody AJ et al, 1984) is a member of the secretin family of hormones. It is synthesized and secreted from endocrine cells in the small intestine. GIP induces insulin secretion, which is primarily stimulated by hyperosmolarity of glucose in the duodenum. Gastric inhibitory polypeptide receptors are found on beta-cells in the pancreas (Volz A et al, 1995). Their effects are mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Bollag RJ et al, 2000).
Literature References
PubMed ID Title Journal Year
10698200 Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors

Isales, CM, Qin, F, Rasmussen, H, Zhong, Q, Bollag, RJ, Zhong, L, Min, L, Phillips, P, Mulloy, AL, Ding, KH, Cameron, R

Endocrinology 2000
6745415 The isolation and sequencing of human gastric inhibitory peptide (GIP)

Valverde, I, Thim, L, Moody, AJ

FEBS Lett 1984
7589426 Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma

Göke, R, Fehmann, HC, Göke, B, Bode, HP, Volz, A, Lankat-Buttgereit, B

FEBS Lett 1995
Orthologous Events
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