Reactome | GIP receptor binds gastric inhibitory peptide

GIP receptor binds gastric inhibitory peptide

Stable Identifier

R-HSA-420274

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

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GIP receptor binds gastric inhibitory peptide

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Gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic peptide) (Moody AJ et al, 1984) is a member of the secretin family of hormones. It is synthesized and secreted from endocrine cells in the small intestine. GIP induces insulin secretion, which is primarily stimulated by hyperosmolarity of glucose in the duodenum. Gastric inhibitory polypeptide receptors are found on beta-cells in the pancreas (Volz A et al, 1995). Their effects are mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Bollag RJ et al, 2000).

Literature References

PubMed ID	Title	Journal	Year
6745415	The isolation and sequencing of human gastric inhibitory peptide (GIP) Moody, AJ, Thim, L, Valverde, I	FEBS Lett	1984
10698200	Osteoblast-derived cells express functional glucose-dependent insulinotropic peptide receptors Bollag, RJ, Zhong, Q, Phillips, P, Min, L, Zhong, L, Cameron, R, Mulloy, AL, Rasmussen, H, Qin, F, Ding, KH, Isales, CM	Endocrinology	2000
7589426	Molecular cloning, functional expression, and signal transduction of the GIP-receptor cloned from a human insulinoma Volz, A, Göke, R, Lankat-Buttgereit, B, Fehmann, HC, Bode, HP, Göke, B	FEBS Lett	1995