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CRHR1 [plasma membrane]
Stable Identifier
R-HSA-420166
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Corticotropin-releasing factor receptor 1, CRFR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CRHR1,CRHR2:CRH [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CRHR1,CRHR2:CRH [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CRHR1,CRHR2:CRH [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CRHR1,CRHR2:CRH [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
CRHR1,CRHR2:CRH [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
GPCRs that activate Gs [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class B/2 (Secretin family receptors) (Homo sapiens)
CRHR1,CRHR2-1 binds CRH,UCN (Homo sapiens)
CRHR1, CRHR2-1 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
CRHR1,CRHR2-1:CRH,UCN [plasma membrane] (Homo sapiens)
CRHR1, CRHR2-1 [plasma membrane] (Homo sapiens)
CRHR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34998 CRHR1
Gene Names
CRHR1, CRFR, CRFR1, CRHR
Chain
signal peptide:1-23, chain:24-415
Reference Genes
BioGPS Gene:104909134 CRHR1
BioGPS Gene:1394 CRHR1
COSMIC (genes):CRHR1 CRHR1
CTD Gene:104909134 CRHR1
CTD Gene:1394 CRHR1
dbSNP Gene:104909134 CRHR1
dbSNP Gene:1394 CRHR1
ENSEMBL:ENSG00000120088 CRHR1
HGNC:2357 CRHR1
KEGG:hsa:104909134 CRHR1
KEGG:hsa:1394 CRHR1
Monarch:104909134 CRHR1
Monarch:1394 CRHR1
NCBI Gene:104909134 CRHR1
NCBI Gene:1394 CRHR1
OMIM:122561 CRHR1
UCSC:P34998 CRHR1
Reference Transcript
RefSeq:NM_004382.4 CRHR1
RefSeq:NM_001303018.1 CRHR1
RefSeq:NM_001145147.1 CRHR1
RefSeq:NM_001303016.1 CRHR1
RefSeq:NM_001145146.1 CRHR1
RefSeq:NM_001256299.2 CRHR1
RefSeq:NM_001145148.1 CRHR1
Other Identifiers
104909134
11732003_a_at
1394
208593_PM_x_at
208593_x_at
211897_PM_s_at
211897_s_at
214619_PM_at
214619_at
3723635
3723636
3723637
3723641
3723642
3723645
3723646
3723647
3723650
3723652
3723653
3723654
3723655
3723656
3723657
3723658
3723659
3723660
3723661
3723662
3723663
3723664
3723666
3723668
40650_r_at
40651_s_at
8007808
A_23_P414884
A_33_P3320443
A_33_P3402817
GE59979
GO:0002376
GO:0004888
GO:0004930
GO:0005515
GO:0005768
GO:0005886
GO:0006955
GO:0007166
GO:0007186
GO:0007189
GO:0007190
GO:0007565
GO:0007567
GO:0008528
GO:0010578
GO:0015056
GO:0016020
GO:0022414
GO:0030325
GO:0031410
GO:0035640
GO:0042596
GO:0043005
GO:0043226
GO:0048149
GO:0048856
GO:0051424
GO:0051458
GO:0051867
GO:0060089
GO:0071376
GO:0098839
GO:0098978
GO:1901386
GO:2000852
HMNXSV003003341
HMNXSV003025307
HMNXSV003056595
Hs.79117.3.S2_3p_at
ILMN_1732426
ILMN_1753706
L23333_s_at
PH_hs_0025074
TC17002239.hg
TC17002876.hg
TC17_ctg5_hap1000028.hg
X72304_at
g5815472_3p_a_at
Participates
as a member of
CRHR1, CRHR2-1 [plasma membrane] (Homo sapiens)
CRHR1, CRHR2 [plasma membrane] (Homo sapiens)
Inferred To
Dh44-R2 [plasma membrane]
(Drosophila melanogaster)
Crhr1 [plasma membrane]
(Mus musculus)
Crhr1 [plasma membrane]
(Rattus norvegicus)
Dh44-R1 [plasma membrane]
(Drosophila melanogaster)
CRHR1 [plasma membrane]
(Canis familiaris)
CRHR1 [plasma membrane]
(Gallus gallus)
CRHR1 [plasma membrane]
(Sus scrofa)
crhr1.2 [plasma membrane]
(Xenopus tropicalis)
Homologues of CRHR1 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001138619.1
,
NP_001289945.1
,
NP_001289947.1
,
NP_004373.2
,
NP_001138620.1
,
NP_001243228.1
,
NP_001138618.1
Guide to Pharmacology - Targets
212
OpenTargets
ENSG00000120088
ENSEMBL
ENSP00000483802
,
ENSP00000477786
,
ENSP00000480752
,
ENST00000616274
,
ENSP00000478177
,
ENST00000615345
,
ENSP00000381333
,
ENSG00000120088
,
ENSP00000484387
,
ENST00000398285
,
ENSP00000326060
,
ENST00000314537
,
ENST00000617905
,
ENSP00000488342
,
ENST00000352855
,
ENST00000618382
,
ENSP00000462016
,
ENSP00000344068
,
ENSG00000278232
,
ENST00000633723
,
ENST00000616748
,
ENST00000577353
,
ENSG00000276191
,
ENST00000613260
,
ENSP00000480396
ZINC - Substances
CRFR1_HUMAN
ZINC - Biogenic
CRFR1_HUMAN
ZINC target
P34998
PRO
P34998
GlyGen
P34998
PDB
8GTM
,
8GTG
,
4K5Y
,
4Z9G
,
8GTI
,
6P9X
,
3EHS
,
3EHT
,
6PB0
,
3EHU
,
2L27
ZINC - Investigational
CRFR1_HUMAN
ZINC - Metabolites
CRFR1_HUMAN
HPA
ENSG00000120088-CRHR1
GeneCards
CRHR1
Pharos - Targets
P34998
ZINC - Predictions - Purchasable
CRFR1_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06850 CRH
1
CRH [extracellular region]
(R-HSA-420146)
0.683
5
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