Reactome | The PACAP receptor binds PACAP

The PACAP receptor binds PACAP

Stable Identifier

R-HSA-420131

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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The pituitary adenylate cyclase-activating peptide (PACAP) (Ohkubo S et al, 1992) is a peptide hormone similar to vasoactive intestinal peptide (VIP). PACAP functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator. Three active peptides are cleaved from the precursor protein; PACAP-related peptide, PACAP-27 and PACAP-38. The effects of the PACAP peptides are mediated by the PACAP receptor (Ogi K et al, 1993). This receptor is predominantly expressed in the CNS. The activity of the receptor is mediated by coupling with the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Ogi K et al, 1993).

Literature References

PubMed ID	Title	Journal	Year
7902709	Molecular cloning and functional expression of a cDNA encoding a human pituitary adenylate cyclase activating polypeptide receptor Masuo, Y, Fujino, M, Ogi, K, Ohtaki, T, Hosoya, M, Masuda, Y, Miyamoto, Y, Habata, Y, Onda, H	Biochem Biophys Res Commun	1993
1739432	Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide Kimura, C, Fujino, M, Arimura, A, Ogi, K, Miyata, A, Hosoya, M, Okazaki, K, Ohkubo, S, Onda, H	DNA Cell Biol	1992