The pituitary adenylate cyclase-activating peptide (PACAP) (Ohkubo S et al, 1992) is a peptide hormone similar to vasoactive intestinal peptide (VIP). PACAP functions as a hypophysiotropic hormone, neurotransmitter and neuromodulator. Three active peptides are cleaved from the precursor protein; PACAP-related peptide, PACAP-27 and PACAP-38. The effects of the PACAP peptides are mediated by the PACAP receptor (Ogi K et al, 1993). This receptor is predominantly expressed in the CNS. The activity of the receptor is mediated by coupling with the G protein alpha s subunit, which stimulates adenylyl cyclase which increases intracellular cAMP levels (Ogi K et al, 1993).
Ohkubo, S, Kimura, C, Ogi, K, Okazaki, K, Hosoya, M, Onda, H, Miyata, A, Arimura, A, Fujino, M
Ogi, K, Miyamoto, Y, Masuda, Y, Habata, Y, Hosoya, M, Ohtaki, T, Masuo, Y, Onda, H, Fujino, M
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