Reactome | CGRP receptor can bind calcitonin gene-related peptides

CGRP receptor can bind calcitonin gene-related peptides

Stable Identifier

R-HSA-420127

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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CGRP receptor can bind calcitonin gene-related peptides

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The calcitonin gene-related peptides alpha-CGRP and beta-CGRP (Morris HR et al, 1984, Steenbergh PH et al, 1985 respectively) are members of the calcitonin family of peptides and are produced in both peripheral and central neurons. They are the most potent peptide vasodilators and can function in the transmission of pain. Their effects are mediated by binding to the CGRP1 receptor (CL) (Aiyar N et al, 1996). CGRP receptors are complexes between CL and receptor activity modifying protein 1 (RAMP1) (Kuwasako K et al, 2004). The activity of the receptor is mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Van Valen et al, 1990).

Literature References

PubMed ID	Title	Journal	Year
2985435	A second human calcitonin/CGRP gene Steenbergh, PH, Höppener, JW, Zandberg, J, Lips, CJ, Jansz, HS	FEBS Lett	1985
2177866	Calcitonin gene-related peptide (CGRP) receptors are linked to cyclic adenosine monophosphate production in SK-N-MC human neuroblastoma cells Van Valen, F, Piechot, G, Jürgens, H	Neurosci Lett	1990
8626685	A cDNA encoding the calcitonin gene-related peptide type 1 receptor Aiyar, N, Rand, K, Elshourbagy, NA, Zeng, Z, Adamou, JE, Bergsma, DJ, Li, Y	J Biol Chem	1996
14722252	Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins Kuwasako, K, Cao, YN, Nagoshi, Y, Tsuruda, T, Kitamura, K, Eto, T	Mol Pharmacol	2004
6609312	Isolation and characterization of human calcitonin gene-related peptide Morris, HR, Panico, M, Etienne, T, Tippins, J, Girgis, SI, MacIntyre, I	Nature	1984