CGRP receptor can bind calcitonin gene-related peptides

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R-HSA-420127
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Reaction [binding]
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Homo sapiens
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The calcitonin gene-related peptides alpha-CGRP and beta-CGRP (Morris HR et al, 1984, Steenbergh PH et al, 1985 respectively) are members of the calcitonin family of peptides and are produced in both peripheral and central neurons. They are the most potent peptide vasodilators and can function in the transmission of pain. Their effects are mediated by binding to the CGRP1 receptor (CL) (Aiyar N et al, 1996). CGRP receptors are complexes between CL and receptor activity modifying protein 1 (RAMP1) (Kuwasako K et al, 2004). The activity of the receptor is mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Van Valen et al, 1990).

Literature References
PubMed ID Title Journal Year
2177866 Calcitonin gene-related peptide (CGRP) receptors are linked to cyclic adenosine monophosphate production in SK-N-MC human neuroblastoma cells

Van Valen, F, Piechot, G, Jürgens, H

Neurosci Lett 1990
2985435 A second human calcitonin/CGRP gene

Steenbergh, PH, Höppener, JW, Zandberg, J, Lips, CJ, Jansz, HS

FEBS Lett 1985
8626685 A cDNA encoding the calcitonin gene-related peptide type 1 receptor

Aiyar, N, Rand, K, Elshourbagy, NA, Zeng, Z, Adamou, JE, Bergsma, DJ, Li, Y

J Biol Chem 1996
14722252 Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins

Kuwasako, K, Cao, YN, Nagoshi, Y, Tsuruda, T, Kitamura, K, Eto, T

Mol Pharmacol 2004
6609312 Isolation and characterization of human calcitonin gene-related peptide

Morris, HR, Panico, M, Etienne, T, Tippins, J, Girgis, SI, MacIntyre, I

Nature 1984
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