Reactome | CGRP receptor can bind calcitonin gene-related peptides

CGRP receptor can bind calcitonin gene-related peptides

Stable Identifier

R-HSA-420127

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

CGRP receptor can bind calcitonin gene-related peptides

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The calcitonin gene-related peptides alpha-CGRP and beta-CGRP (Morris HR et al, 1984, Steenbergh PH et al, 1985 respectively) are members of the calcitonin family of peptides and are produced in both peripheral and central neurons. They are the most potent peptide vasodilators and can function in the transmission of pain. Their effects are mediated by binding to the CGRP1 receptor (CL) (Aiyar N et al, 1996). CGRP receptors are complexes between CL and receptor activity modifying protein 1 (RAMP1) (Kuwasako K et al, 2004). The activity of the receptor is mediated by coupling to the G protein alpha s subunit, which stimulates adenylyl cyclase which can increase intracellular cAMP levels (Van Valen et al, 1990).

Literature References

PubMed ID	Title	Journal	Year
2985435	A second human calcitonin/CGRP gene Höppener, JW, Steenbergh, PH, Lips, CJ, Jansz, HS, Zandberg, J	FEBS Lett	1985
2177866	Calcitonin gene-related peptide (CGRP) receptors are linked to cyclic adenosine monophosphate production in SK-N-MC human neuroblastoma cells Jürgens, H, Piechot, G, Van Valen, F	Neurosci Lett	1990
8626685	A cDNA encoding the calcitonin gene-related peptide type 1 receptor Zeng, Z, Elshourbagy, NA, Li, Y, Bergsma, DJ, Rand, K, Adamou, JE, Aiyar, N	J Biol Chem	1996
14722252	Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins Eto, T, Kitamura, K, Kuwasako, K, Cao, YN, Tsuruda, T, Nagoshi, Y	Mol Pharmacol	2004
6609312	Isolation and characterization of human calcitonin gene-related peptide Girgis, SI, Tippins, J, Panico, M, Morris, HR, MacIntyre, I, Etienne, T	Nature	1984