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p-T505-LIMK2 [cytosol]
Stable Identifier
R-HSA-419711
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
LIM domain kinase 2, phosphorylated (Thr-505), LIMK2, LIMK2_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
p-LIMK [cytosol] (Homo sapiens)
p-T505-LIMK2 [cytosol] (Homo sapiens)
ROCK phosphorylates LIMK1,2 (Homo sapiens)
p-LIMK [cytosol] (Homo sapiens)
p-T505-LIMK2 [cytosol] (Homo sapiens)
Semaphorin interactions (Homo sapiens)
Sema4D in semaphorin signaling (Homo sapiens)
Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
LIM kinase phosphorylation by ROCK (Homo sapiens)
p-LIMK [cytosol] (Homo sapiens)
p-T505-LIMK2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
LIM kinase phosphorylation by ROCK (Homo sapiens)
p-LIMK [cytosol] (Homo sapiens)
p-T505-LIMK2 [cytosol] (Homo sapiens)
LIMK phosphorylates CFL1, inactivating it (Homo sapiens)
p-LIMK [cytosol] (Homo sapiens)
p-T505-LIMK2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53671 LIMK2
Gene Names
LIMK2
Chain
chain:1-638
Reference Genes
BioGPS Gene:3985 LIMK2
COSMIC (genes):LIMK2 LIMK2
CTD Gene:3985 LIMK2
dbSNP Gene:3985 LIMK2
ENSEMBL:ENSG00000182541.18 LIMK2
HGNC:6614 LIMK2
KEGG Gene (Homo sapiens):3985 LIMK2
Monarch:3985 LIMK2
NCBI Gene:3985 LIMK2
OMIM:601988 LIMK2
UCSC:P53671 LIMK2
Reference Transcript
RefSeq:NM_001031801.1 LIMK2
RefSeq:NM_005569.3 LIMK2
RefSeq:NM_016733.2 LIMK2
Other Identifiers
0004210463
0004920053
11733509_a_at
11734740_a_at
11734741_x_at
11734742_a_at
11739042_x_at
11739043_a_at
11750802_x_at
11757632_s_at
16929163
202193_PM_at
202193_at
210582_PM_s_at
210582_s_at
212680_PM_x_at
217475_PM_s_at
217475_s_at
2786521
3376816
3376820
38617_at
38618_at
3942839
3942840
3942843
3942844
3942845
3942846
3942847
3942852
3942855
3942856
3942860
3942861
3942863
3942864
3942865
3942866
3942867
3942869
3942870
3942872
3942878
3942879
3942880
3942881
3942882
3942883
3942884
3942885
3942886
3942887
3942905
3985
3999730
8072461
A_23_P211445
D45906_at
D85527_at
GE61667
GE79610
GO:0000166
GO:0001934
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005622
GO:0005634
GO:0005737
GO:0005794
GO:0005801
GO:0005813
GO:0005815
GO:0005819
GO:0005856
GO:0006468
GO:0007010
GO:0007283
GO:0016301
GO:0016310
GO:0016740
GO:0022414
GO:0030036
GO:0030953
GO:0036211
GO:0042325
GO:0043226
GO:0043229
GO:0044782
GO:0046872
GO:0048471
GO:0048856
GO:0051650
GO:0060322
GO:0061303
GO:0072686
GO:0106310
GO:0140096
GO:1900182
GO:1902018
HMNXSV003040135
HMNXSV003046202
Hs.278027.2.S1_3p_a_at
ILMN_1660624
ILMN_1721094
ILMN_2270443
PH_hs_0014254
PH_hs_0032433
TC22000224.hg
g5911930_3p_a_at
Participates
as a candidate of
p-LIMK [cytosol] (Homo sapiens)
Other forms of this molecule
LIMK2 [cytosol]
Modified Residues
Name
O-phospho-L-threonine at 505
Coordinate
505
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_005560.1
,
NP_057952.1
,
NP_001026971.1
ZINC - World Drugs
LIMK2_HUMAN
Guide to Pharmacology - Targets
2055
OpenTargets
ENSG00000182541
ZINC - FDA approved
LIMK2_HUMAN
ZINC - Substances
LIMK2_HUMAN
ZINC - Biogenic
LIMK2_HUMAN
ZINC target
P53671
PRO
P53671
PDB
5NXD
,
7QHG
,
1X6A
,
4TPT
ZINC - Investigational
LIMK2_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000182541-LIMK2
GeneCards
P53671
Ensembl
ENST00000331728
,
ENST00000340552
,
ENSG00000182541
,
ENST00000333611
,
ENSP00000332687
,
ENSP00000339916
,
ENSP00000330470
Pharos - Targets
P53671
ZINC - Predictions - Purchasable
LIMK2_HUMAN
HMDB Protein
HMDBP09475
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.641
3
UniProt:Q13451 FKBP5
2
FKBP5 [cytosol]
(R-HSA-5618096)
FKBP5 [nucleoplasm]
(R-HSA-8939165)
0.527
2
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