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PPP1R12B [cytosol]
Stable Identifier
R-HSA-419178
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Protein phosphatase 1 regulatory subunit 12B, Myosin phosphatase-targeting subunit 2, MYPT2_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate ROCKs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
Myosin phosphatase inactivation by ROCK (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
p-T696,S852-MYPT1-Myosin Phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
RHO GTPases activate CIT (Homo sapiens)
Activated CIT phosphorylates MRLCs (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
RHO GTPases activate PAKs (Homo sapiens)
MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
PAK1 phosphorylates myosin phosphatase (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
p-T696-PPP1R12A-Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
RHO GTPases activate PKNs (Homo sapiens)
Myosin phosphatase dephosphorylates myosin regulatory light chain (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
p-T38-PPP1R14A binds MLCP (Homo sapiens)
MLCP:p-T38-PPP1R14A [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
PPP1R12B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60237 PPP1R12B
Gene Names
PPP1R12B, MYPT2
Chain
chain:1-982
Reference Genes
BioGPS Gene:4660 PPP1R12B
COSMIC (genes):PPP1R12B PPP1R12B
CTD Gene:4660 PPP1R12B
dbSNP Gene:4660 PPP1R12B
ENSEMBL:ENSG00000077157 PPP1R12B
HGNC:7619 PPP1R12B
KEGG:hsa:4660 PPP1R12B
Monarch:4660 PPP1R12B
NCBI Gene:4660 PPP1R12B
OMIM:603768 PPP1R12B
UCSC:O60237 PPP1R12B
Reference Transcript
RefSeq:NM_032103.2 PPP1R12B
RefSeq:NM_001331029.1 PPP1R12B
RefSeq:NM_001197131.1 PPP1R12B
RefSeq:XM_017001354.1 PPP1R12B
RefSeq:XM_017001352.1 PPP1R12B
RefSeq:NM_002481.3 PPP1R12B
RefSeq:NM_001167857.1 PPP1R12B
RefSeq:NM_032104.2 PPP1R12B
RefSeq:XM_017001353.1 PPP1R12B
RefSeq:NM_001167858.1 PPP1R12B
Participates
as a component of
p-T696,S852-MYPT1-Myosin Phosphatase [cytosol] (Homo sapiens)
p-T696-PPP1R12A-Myosin phosphatase [cytosol] (Homo sapiens)
Myosin phosphatase [cytosol] (Homo sapiens)
Inferred To
Ppp1r12b [cytosol]
(Mus musculus)
Ppp1r12b [cytosol]
(Rattus norvegicus)
Mbs [cytosol]
(Drosophila melanogaster)
mel-11 [cytosol]
(Caenorhabditis elegans)
ppp1r12a [cytosol]
(Danio rerio)
ppp1r12a [cytosol]
(Xenopus tropicalis)
PPP1R12B [cytosol]
(Bos taurus)
PPP1R12B [cytosol]
(Canis familiaris)
PPP1R12B [cytosol]
(Gallus gallus)
PPP1R12B [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENSP00000349206
,
ENSP00000375821
,
ENSG00000077157
,
ENSP00000480852
,
ENST00000608999
,
ENST00000290419
,
ENST00000356764
,
ENST00000480184
,
ENSP00000417159
,
ENST00000391959
,
ENST00000491336
,
ENSP00000476755
,
ENSP00000484005
OpenTargets
ENSG00000077157
GeneCards
PPP1R12B
HPA
ENSG00000077157-PPP1R12B
PRO
O60237
Pharos - Targets
O60237
GlyGen
O60237
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75344 FKBP6
2
FKBP6 [nucleoplasm]
(R-HSA-912512)
FKBP6 [cytosol]
(R-HSA-5601923)
0.527
2
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