Reactome | GEFs activate RhoA,B,C

GEFs activate RhoA,B,C

Stable Identifier

R-HSA-419166

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Guanine nucleotide exchange factors (GEFs) activate GTPases by enhancing the exchange of bound GDP for GTP. Much evidence points to GEFs being critical mediators of Rho GTPase activation (Schmidt and Hall, 2002). Many GEFs are known to be highly specific for a particular GTPase, e.g. Fgd1/Cdc42 and p115RhoGEF/Rho (Hart et al., 1996, Zheng et al., 1996). Others have a broader spectrum and activate several GTPases, e.g. Vav1 for Rac, Rho, and Cdc42 (Hart et al, 1994).

Literature References

PubMed ID	Title	Journal	Year
9308960	Rho GTPases and signaling networks Van Aelst, L, D'Souza-Schorey, C	Genes Dev	1997
16212495	Rho GTPases: biochemistry and biology Jaffe, AB, Hall, A	Annu Rev Cell Dev Biol	2005
12101119	Guanine nucleotide exchange factors for Rho GTPases: turning on the switch Schmidt, A, Hall, A	Genes Dev	2002