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PDE10A [cytosol]
Stable Identifier
R-HSA-418536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 10A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, PDE10_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
cGMP is degraded by PDEs (Homo sapiens)
cGMP phosphodiesterases [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE10A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE10A [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:Q9Y233 PDE10A
Gene Names
PDE10A
Chain
chain:1-1055
Reference Genes
BioGPS Gene:10846 PDE10A
COSMIC (genes):PDE10A PDE10A
CTD Gene:10846 PDE10A
dbSNP Gene:10846 PDE10A
ENSEMBL:ENSG00000112541 PDE10A
HGNC:8772 PDE10A
KEGG:hsa:10846 PDE10A
Monarch:10846 PDE10A
NCBI Gene:10846 PDE10A
OMIM:610652 PDE10A
UCSC:Q9Y233 PDE10A
Reference Transcript
RefSeq:NM_006661.3 PDE10A
RefSeq:NM_001130690.2 PDE10A
RefSeq:XM_011535388.2 PDE10A
Other Identifiers
10846
11736799_a_at
11736800_a_at
11741718_a_at
11753937_at
11755666_a_at
11757219_at
17025523
17025555
17025560
205501_PM_at
205501_at
211170_PM_s_at
211170_s_at
211171_PM_s_at
211171_s_at
230251_PM_at
230251_at
2984277
2984278
2984279
2984280
2984281
2984282
2984283
2984284
2984286
2984287
2984290
2984297
2984300
2984303
2984304
2984305
2984306
2984308
2984309
2984310
2984312
2984313
2984314
2984315
2984316
2984319
2984320
2984323
2984331
2984332
2984333
2984341
2984342
2984355
2984357
2984358
2984359
2984360
2984361
2984363
2984364
2984365
2984366
2984378
2984379
2984380
2984388
2984390
2984391
2984395
2984399
2984403
2984405
2984406
2984407
2984408
2984409
2984410
2984411
2984415
2984416
2984418
2984419
2984420
2984425
2984426
2984427
2984447
2984448
2984470
2984471
2984473
35522_at
45888_at
71435_at
76100_at
8130674
90632
ADDON000917.hg
A_21_P0005182
A_23_P356677
A_24_P636301
A_32_P173227
A_32_P8546
A_33_P3258127
A_33_P3394272
GE53519
GE633447
GE663759
GE760729
GE827630
GO:0003824
GO:0004114
GO:0004115
GO:0004118
GO:0005515
GO:0005737
GO:0005829
GO:0006198
GO:0007165
GO:0008081
GO:0010754
GO:0016787
GO:0019933
GO:0030552
GO:0030553
GO:0046069
GO:0046872
GO:0047555
GO:0055086
GO:1901135
HMNXSV003007375
HMNXSV003011753
HMNXSV003014668
HMNXSV003018864
HMNXSV003023425
HMNXSV003039327
Hs.128291.0.S2_3p_at
Hs.128291.1.S2_3p_a_at
Hs.31917.0.A1_3p_at
ILMN_1782955
ILMN_1908918
ILMN_2121272
PH_hs_0012354
PH_hs_0016826
PH_hs_0025054
PH_hs_0037649
PH_hs_0037844
TC06002297.hg
TC06002300.hg
TC06002301.hg
TC06002302.hg
TC06003988.hg
TC06003991.hg
TC06003993.hg
g5902441_3p_a_at
p14411
p14413
p14414
p14415
p14416
p14417
p14418
p25402
p29936
Participates
as a member of
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
Inferred To
PDE10A [cytosol]
(Bos taurus)
PDE10A [cytosol]
(Caenorhabditis elegans)
PDE10A [cytosol]
(Canis familiaris)
PDE10A [cytosol]
(Gallus gallus)
PDE10A [cytosol]
(Mus musculus)
PDE10A [cytosol]
(Rattus norvegicus)
PDE10A [cytosol]
(Sus scrofa)
Cross References
Guide to Pharmacology - Targets
1310
OpenTargets
ENSG00000112541
ENSEMBL
ENSG00000112541
,
ENST00000539869
,
ENSP00000438284
ZINC - FDA approved
PDE10_HUMAN
ZINC - Substances
PDE10_HUMAN
ZINC - Biogenic
PDE10_HUMAN
ZINC target
Q9Y233
PRO
Q9Y233
GlyGen
Q9Y233
PDB
5SII
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4P1R
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5SHY
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5SEJ
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5SG8
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5SEO
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5SF9
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6KE0
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5SGU
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5EDG
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5SHU
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5SE7
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5SE2
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5SFC
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5SJD
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4HEU
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5SIT
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7BPI
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5UWF
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5SJP
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5SFZ
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5SFS
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5SGB
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5SGQ
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5SHB
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5SFJ
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5SFW
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3UUO
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5SJ3
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5SJM
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2OUR
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5SKC
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5SK8
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5SGE
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4MSA
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5SIJ
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5SH1
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5SED
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5SF5
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5SIL
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5SJ6
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5SJJ
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5SJB
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4MVH
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5SI1
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4MRZ
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5SKG
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5SE5
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5SGI
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5SF1
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5SFA
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5SEX
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5SI3
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5SEG
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5SFK
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3SN7
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2OUS
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5SDX
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5SEC
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5SHA
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4MUW
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5SID
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5SGK
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5SFE
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6KZE
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5SGX
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5SIS
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7QPF
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5SIB
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5SER
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4LM0
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5SFR
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5SJS
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5SGY
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5SGT
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5SFM
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4TPM
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5SJO
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5SK7
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5SGO
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5DH5
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5SF4
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5SGL
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2Y0J
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5SGD
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5B4L
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5I2R
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5C28
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5SEE
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5SJA
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5SKE
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5SIE
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2OUY
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5SGW
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5SHW
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5SEQ
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4ZO5
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5SFI
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5SGR
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4AJD
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4P0N
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5SJT
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7QPV
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5SJ7
,
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5SKD
,
5SJX
,
5SFY
,
4LM1
,
5SG2
,
5SJN
IntEnz
3.1.4.17
HPA
ENSG00000112541-PDE10A
GeneCards
PDE10A
Pharos - Targets
Q9Y233
Orphanet
PDE10A
ZINC - Predictions - Purchasable
PDE10_HUMAN
HMDB Protein
HMDBP00604
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