Reactome | PDE10A [cytosol]

PDE10A [cytosol]

Stable Identifier

R-HSA-418536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphodiesterase 10A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, PDE10_HUMAN

Locations in the PathwayBrowser

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Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Nitric oxide stimulates guanylate cyclase (Homo sapiens)
    - cGMP effects (Homo sapiens)
      - cGMP is degraded by PDEs (Homo sapiens)
        
        cGMP phosphodiesterases [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE10A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - cAMP degradation by Phosphodiesterases (Homo sapiens)
        
        cAMP PDEs [cytosol] (Homo sapiens)
        
        Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
        
        PDE10A [cytosol] (Homo sapiens)

General

Can hydrolyze both cAMP and cGMP

External Reference Information

External Reference

UniProt:Q9Y233 PDE10A

Gene Names

PDE10A

Chain

chain:1-779

Reference Genes

BioGPS Gene:10846 PDE10A

COSMIC (genes):PDE10A PDE10A

CTD Gene:10846 PDE10A

dbSNP Gene:10846 PDE10A

ENSEMBL:ENSG00000112541 PDE10A

HGNC:8772 PDE10A

KEGG Gene (Homo sapiens):10846 PDE10A

Monarch:10846 PDE10A

NCBI Gene:10846 PDE10A

OMIM:610652 PDE10A

UCSC:Q9Y233 PDE10A

Reference Transcript

Other Identifiers

0003520333

10846

11736799_a_at

11736800_a_at

11741718_a_at

11755666_a_at

17025523

205501_at

211170_s_at

211171_s_at

2984277

2984278

2984279

2984280

2984281

2984282

2984283

2984286

2984287

2984290

2984297

2984300

2984303

2984304

2984305

2984306

2984308

2984310

2984312

2984313

2984314

2984315

2984316

2984319

2984320

2984323

2984332

2984333

2984363

2984364

35522_at

76100_at

8130674

90632

A_23_P356677

GE53519

GE663759

GO:0000166

GO:0003674

GO:0003824

GO:0004114

GO:0004115

GO:0004118

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006198

GO:0007165

GO:0007186

GO:0008081

GO:0008150

GO:0008152

GO:0009056

GO:0009058

GO:0010754

GO:0016787

GO:0030552

GO:0030553

GO:0034641

GO:0034655

GO:0043167

GO:0044281

GO:0046069

GO:0046872

GO:0047555

HMNXSV003018864

Hs.128291.0.S2_3p_at

Hs.128291.1.S2_3p_a_at

ILMN_1782955

ILMN_2121272

PH_hs_0016826

PH_hs_0025054

TC06002297.hg

TC06003988.hg

g5902441_3p_a_at

Participates

as a member of

Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)

Inferred To

pde-5 [cytosol] (Caenorhabditis elegans)

pde3 [cytosol] (Dictyostelium discoideum)

pde10a [cytosol] (Danio rerio)

Pde10a [cytosol] (Mus musculus)

Pde10a [cytosol] (Rattus norvegicus)

PDE10A [cytosol] (Bos taurus)

PDE10A [cytosol] (Canis familiaris)

PDE10A [cytosol] (Gallus gallus)

PDE10A [cytosol] (Sus scrofa)

PDE10A [cytosol] (Xenopus tropicalis)

PDE2 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_006652.1, NP_001124162.1, XP_011533690.1

ZINC - World Drugs

PDE10_HUMAN

Guide to Pharmacology - Targets

1310

OpenTargets

ENSG00000112541

ZINC - FDA approved

PDE10_HUMAN

ZINC - Substances

PDE10_HUMAN

ZINC target

Q9Y233

ZINC - Biogenic

PDE10_HUMAN

PRO

Q9Y233

GlyGen

Q9Y233

PDB

6KO1, 4AJM, 2WEY, 4FCD, 5I2R, 4FCB, 5C2H, 4LM1, 4LM2, 4PHW, 3WS8, 6MSC, 5AXQ, 4TPM, 5DH5, 4HF4, 4LLP, 2OUU, 5K9R, 4BBX, 2OUS, 5C29, 4LLK, 5B4L, 4YS7, 3SNI, 2OUR, 2OUQ, 4MSH, 5B4K, 3WS9, 5C1W, 4LLJ, 6IJH, 3UUO, 5EDE, 4MVH, 4XY2, 4LKQ, 4MSA, 4MUW, 4AJD, 4HEU, 7BPI, 4DDL, 5UWF, 6KZE, 5EDI, 6KDX, 3WYK, 4MS0, 6KO0, 4AEL, 5EDH, 6KDZ, 5XUI, 2ZMF, 5EDG, 4LM3, 5XUJ, 4LM4, 4TPP, 4AJG, 4P0N, 6MSA, 5C2E, 4LLX, 2OUV, 5C2A, 4LM0, 2OUY, 4WN1, 5AXP, 3SNL, 4MSN, 5DH4, 1LRB, 4DFF, 5ZNL, 5C28, 2Y0J, 4MSE, 2OUP, 4MSC, 6IJI, 3WI2, 3UI7, 4AJF, 2OUN, 3SN7, 3WYM, 4ZO5, 4YQH, 4P1R, 3WYL, 4MRW, 4MRZ, 6KE0

IntEnz

3.1.4.17

GeneCards

Q9Y233

HPA

ENSG00000112541-PDE10A

Ensembl

ENSP00000355847, ENST00000366882, ENSG00000112541

Pharos - Targets

Q9Y233

ZINC - Predictions - Purchasable

PDE10_HUMAN

Orphanet

26009

HMDB Protein

HMDBP00604