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PDE10A [cytosol]
Stable Identifier
R-HSA-418536
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Phosphodiesterase 10A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, PDE10_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Nitric oxide stimulates guanylate cyclase (Homo sapiens)
cGMP effects (Homo sapiens)
cGMP is degraded by PDEs (Homo sapiens)
cGMP phosphodiesterases [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE10A [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (s) signalling events (Homo sapiens)
cAMP degradation by Phosphodiesterases (Homo sapiens)
cAMP PDEs [cytosol] (Homo sapiens)
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
PDE10A [cytosol] (Homo sapiens)
General
Can hydrolyze both cAMP and cGMP
External Reference Information
External Reference
UniProt:Q9Y233 PDE10A
Gene Names
PDE10A
Chain
chain:1-779
Reference Genes
BioGPS Gene:10846 PDE10A
COSMIC (genes):PDE10A PDE10A
CTD Gene:10846 PDE10A
dbSNP Gene:10846 PDE10A
ENSEMBL:ENSG00000112541.19 PDE10A
HGNC:8772 PDE10A
KEGG Gene (Homo sapiens):10846 PDE10A
Monarch:10846 PDE10A
NCBI Gene:10846 PDE10A
OMIM:610652 PDE10A
UCSC:Q9Y233 PDE10A
Reference Transcript
RefSeq:NM_006661.3 PDE10A
RefSeq:NM_001130690.2 PDE10A
RefSeq:XM_011535388.2 PDE10A
Other Identifiers
0003520333
10846
11736799_a_at
11736800_a_at
11741718_a_at
11755666_a_at
17025523
205501_PM_at
205501_at
211170_PM_s_at
211170_s_at
211171_PM_s_at
211171_s_at
2984277
2984278
2984279
2984280
2984281
2984282
2984283
2984286
2984287
2984290
2984297
2984300
2984303
2984304
2984305
2984306
2984308
2984310
2984312
2984313
2984314
2984315
2984316
2984323
2984332
2984333
2984427
35522_at
76100_at
8130674
90632
A_23_P356677
GE53519
GE663759
GO:0000166
GO:0003824
GO:0004114
GO:0004115
GO:0004118
GO:0005515
GO:0005622
GO:0005737
GO:0005829
GO:0006198
GO:0007165
GO:0008081
GO:0008152
GO:0010754
GO:0016787
GO:0023052
GO:0030552
GO:0030553
GO:0046069
GO:0046872
GO:0047555
GO:0055086
GO:1901135
HMNXSV003011753
HMNXSV003018864
Hs.128291.0.S2_3p_at
Hs.128291.1.S2_3p_a_at
ILMN_1782955
ILMN_2121272
PH_hs_0016826
PH_hs_0025054
TC06002297.hg
TC06003988.hg
g5902441_3p_a_at
Participates
as a member of
Phosphodiesterases, dual (cAMP, cGMP) activity [cytosol] (Homo sapiens)
Inferred To
PDE10A [cytosol]
(Bos taurus)
PDE10A [cytosol]
(Caenorhabditis elegans)
PDE10A [cytosol]
(Canis familiaris)
PDE10A [cytosol]
(Danio rerio)
PDE10A [cytosol]
(Gallus gallus)
PDE10A [cytosol]
(Mus musculus)
PDE10A [cytosol]
(Rattus norvegicus)
PDE10A [cytosol]
(Sus scrofa)
PDE10A [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
NP_006652.1
,
NP_001124162.1
,
XP_011533690.1
ZINC - World Drugs
PDE10_HUMAN
Guide to Pharmacology - Targets
1310
OpenTargets
ENSG00000112541
ZINC - FDA approved
PDE10_HUMAN
ZINC - Substances
PDE10_HUMAN
ZINC target
Q9Y233
ZINC - Biogenic
PDE10_HUMAN
PRO
Q9Y233
PDB
5AXQ
,
6KO1
,
4LLJ
,
6MSC
,
4MRZ
,
4MUW
,
3SN7
,
5C2A
,
6KO0
,
6KDZ
,
4MRW
,
5DH4
,
4LM4
,
5C28
,
6MSA
,
6KDX
,
5XUJ
,
4LM0
,
4MSE
,
5ZNL
,
5EDH
,
5C2H
,
4LLP
,
3WS8
,
4MSA
,
4AJM
,
5I2R
,
5EDE
,
2Y0J
,
4HEU
,
4MSN
,
3WYM
,
2OUU
,
6KZE
,
4AJF
,
4P1R
,
4ZO5
,
3SNL
,
2WEY
,
5DH5
,
2OUR
,
2OUS
,
4DDL
,
3WS9
,
5C1W
,
4HF4
,
2ZMF
,
4XY2
,
2OUQ
,
4TPP
,
5UWF
,
3UUO
,
3WI2
,
4LLK
,
7BPI
,
4MS0
,
6IJI
,
5C2E
,
5AXP
,
6KE0
,
3UI7
,
4YS7
,
4LM3
,
6IJH
,
4DFF
,
5C29
,
5B4L
,
4FCD
,
4BBX
,
4MSC
,
2OUP
,
4LM1
,
5XUI
,
3SNI
,
5EDG
,
4FCB
,
4AEL
,
4MVH
,
4LLX
,
2OUN
,
4PHW
,
4WN1
,
4YQH
,
4AJG
,
2OUV
,
4MSH
,
3WYK
,
4AJD
,
3WYL
,
5EDI
,
5K9R
,
5B4K
,
4LM2
,
2OUY
,
4P0N
,
4LKQ
,
4TPM
IntEnz
3.1.4.17
GeneCards
Q9Y233
HPA
ENSG00000112541-PDE10A
Ensembl
ENSP00000355847
,
ENSG00000112541
,
ENST00000366882
Pharos - Targets
Q9Y233
Orphanet
26009
ZINC - Predictions - Purchasable
PDE10_HUMAN
HMDB Protein
HMDBP00604
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