Reactome | p190RhoGAP binds Plexin-B1

p190RhoGAP binds Plexin-B1

Stable Identifier

R-HSA-416562

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D mediated inhibition of cell attachment and migration (Homo sapiens)
        
        p190RhoGAP binds Plexin-B1 (Homo sapiens)

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Plexin-B1 can mediate inhibition of RhoA via the Sema4D-dependent recruitment of p190RhoGAP into the semaphorin receptor complex.

Literature References

PubMed ID	Title	Journal	Year
16188938	p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling Artigiani, S, Sordella, R, Corso, S, Tamagnone, L, Barberis, D, Casazza, A, Comoglio, PM, Settleman, J	J Cell Sci	2005