Reactome | ARHGEF12 [cytosol]

ARHGEF12 [cytosol]

Stable Identifier

R-HSA-416560

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Rho guanine nucleotide exchange factor 12, ARHGC_HUMAN, LARG

Locations in the PathwayBrowser for interactor UniProt:Q9P0L0 VAPA

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External Reference Information

External Reference

UniProt:Q9NZN5 ARHGEF12

Gene Names

ARHGEF12, KIAA0382, LARG

Chain

initiator methionine:1, chain:2-1544

Reference Genes

BioGPS Gene:23365 ARHGEF12

COSMIC - genes:ARHGEF12 ARHGEF12

CTD Gene:23365 ARHGEF12

dbSNP Gene:23365 ARHGEF12

ENSEMBL:ENSG00000196914 ARHGEF12

HGNC:14193 ARHGEF12

KEGG:hsa:23365 ARHGEF12

Monarch:23365 ARHGEF12

NCBI Gene:23365 ARHGEF12

OMIM:604763 ARHGEF12

UCSC:Q9NZN5 ARHGEF12

Reference Transcript

Participates

as a member of

as a candidate of

CDC42 GEFs [cytosol] (Homo sapiens)

as a component of

G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)

as an input of

LARG activation by G alpha 12/13 (Homo sapiens)

Inferred To

RhoGEF2 [cytosol] (Drosophila melanogaster)

rhgf-1 [cytosol] (Caenorhabditis elegans)

arhgef12 [cytosol] (Xenopus tropicalis)

arhgef12a [cytosol] (Danio rerio)

ARHGEF12 [cytosol] (Bos taurus)

ARHGEF12 [cytosol] (Canis familiaris)

ARHGEF12 [cytosol] (Gallus gallus)

ARHGEF12 [cytosol] (Sus scrofa)

Arhgef12 [cytosol] (Mus musculus)

Arhgef12 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001288013.1, XP_011541022.1, NP_001185594.1, XP_016872910.1, NP_056128.1

ENSEMBL

ENSP00000380942, ENSG00000196914, ENST00000397843, ENST00000356641, ENSP00000349056

OpenTargets

ENSG00000196914

GeneCards

ARHGEF12

HPA

ENSG00000196914-ARHGEF12

PRO

Q9NZN5

Pharos - Targets

Q9NZN5

GlyGen

Q9NZN5

HMDB Protein

HMDBP11507

PDB

1X86, 2OMJ, 1TXD, 2OS6

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.77	4
UniProt:O14908 GIPC1	1	GIPC1 [cytoplasm] (R-HSA-9839329)	0.723	8
UniProt:Q9P0L0 VAPA	4	VAPA [endoplasmic reticulum membrane] (R-HSA-429677) VAPA [azurophil granule membrane] (R-HSA-6799364) VAPA [plasma membrane] (R-HSA-6806269) VAPA [cytosol] (R-HSA-9609920)	0.706	7
UniProt:Q9UM54 MYO6	3	MYO6 [plasma membrane] (R-HSA-3006691) MYO6 [lysosomal membrane] (R-HSA-3006694) MYO6 [cytosol] (R-HSA-3006692)	0.7	6
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.65	7
UniProt:O95292 VAPB	2	VAPB [endoplasmic reticulum membrane] (R-HSA-429718) VAPB [Golgi membrane] (R-HSA-9715115)	0.643	5
UniProt:P61793	1	LPAR1 [plasma membrane] (R-MMU-419354)	0.524	3
UniProt:Q9Q2G4 Q9Q2G4			0.462	2

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