p-TIAM1 exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-4093336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Phosphorylated T-lymphoma invasion and metastasis-inducing protein 1 (p-TIAM1) bound to EPHB complexes containing NMDARs, promotes spine morphogenesis by activating RAC1, which triggers actin cytoskeletal remodelling that is essential for spine development (Tolias et al. 2007, Tolias et al. 2005).
Literature References
PubMed ID Title Journal Year
15721239 The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines

Greenberg, ME, Tavazoie, S, Harrar, D, Paradis, S, Burette, A, Weinberg, RJ, Bikoff, JB, Tolias, KF

Neuron 2005
Participants
Participates
Catalyst Activity

guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane]

Orthologous Events
Authored
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Created
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