p-TIAM1 exchanges GTP for GDP on RAC1, activating it

Stable Identifier
R-HSA-4093336
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Phosphorylated T-lymphoma invasion and metastasis-inducing protein 1 (p-TIAM1) bound to EPHB complexes containing NMDARs, promotes spine morphogenesis by activating RAC1, which triggers actin cytoskeletal remodelling that is essential for spine development (Tolias et al. 2007, Tolias et al. 2005).

Literature References
PubMed ID Title Journal Year
15721239 The Rac1-GEF Tiam1 couples the NMDA receptor to the activity-dependent development of dendritic arbors and spines

Tolias, KF, Bikoff, JB, Burette, A, Paradis, S, Harrar, D, Tavazoie, S, Weinberg, RJ, Greenberg, ME

Neuron 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of EFNBs:p-EPHBs:SFKs:Glu:p-NMDAR:Gly:p-Y829-TIAM1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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