FOXM1 stimulates CENPF transcription

Stable Identifier
R-HSA-4088441
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
FOXM1 stimulates CENPF transcription
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

FOXM1 stimulates the transcription of the kinetochore protein CENPF. FOXM1-depleted cells have reduced CENPF levels, leading to the misalignment of mitotic chromosomes (Laoukili et al. 2005).

Literature References
PubMed ID Title Journal Year
15654331 FoxM1 is required for execution of the mitotic programme and chromosome stability

Kooistra, MR, Brás, A, Medema, RH, Clevers, HC, Kauw, J, Laoukili, J, Morrison, A, Kerkhoven, RM

Nat. Cell Biol. 2005
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-T611,S730,S739-FOXM1:CENPF Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-T611,S730,S739-FOXM1 [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-08-14)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-08-13)
Cite Us!