FOXM1 stimulates PLK1 transcription

Stable Identifier
R-HSA-4088305
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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FOXM1 stimulates PLK1 transcription
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FOXM1 bound to the MuvB complex (consisting of LIN9, LIN37, LIN52, LIN54 and RBBP4) and MYBL2 (B-MYB) stimulates PLK1 transcription. This creates a positive feedback loop, where PLK1 phosphorylates and activates FOXM1 (Fu et al. 2008), while FOXM1 transcriptional activity results in increased PLK1 levels. MuvB and FOXM1 may persist on the PLK1 promoter throughout G2, while MYBL2 may gradually dissociate from the PLK1 promoter due to proteasome-mediated degradation initiated when MYBL2 is phosphorylated by CCNA (cyclin A)-associated CDKs (Sadasivam et al. 2012).
Literature References
PubMed ID Title Journal Year
22391450 The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expression

Sadasivam, S, Duan, S, DeCaprio, JA

Genes Dev. 2012
19160488 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z, Malureanu, L, Huang, J, Wang, W, Li, H, van Deursen, JM, Tindall, DJ, Chen, J

Nat. Cell Biol. 2008
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-T611,S730,S739-FOXM1:MuvB:MYBL2:PLK1 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-T611,S730,S739-FOXM1 [nucleoplasm]
MYBL2 [nucleoplasm]
MuvB complex [nucleoplasm]
Authored
Orlic-Milacic, M  (2013-08-14)
Reviewed
Bruinsma, W  (2013-08-21)
Created
Orlic-Milacic, M  (2013-08-12)
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