Reactome | LUM (lumican) binds integrin alpha2beta1

LUM (lumican) binds integrin alpha2beta1

Stable Identifier

R-HSA-4085133

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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LUM (lumican) binds integrin alpha2beta1

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Lumican (LUM) is the major leucine-rich keratan sulfate proteoglycan of the corneal stroma, also found in the extracellular matrices of skin, muscle and cartilage. Lum null mice have corneal opacity as well as skin and tendon fragility associated with disorganized and loosely packed collagen fibers (Jepsen et al. 2002, Chakravarti et al. 2003). LUM binds integrin alpha2beta1 (Zeltz et al. 2010), downregulating MMP-14 expression (Niewiarowska et al. 2011).

Literature References

PubMed ID	Title	Journal	Year
20705068	Lumican inhibits cell migration through ?2?1 integrin Zeltz, C, Brezillon, S, Käpylä, J, Eble, JA, Bobichon, H, Terryn, C, Perreau, C, Franz, CM, Heino, J, Maquart, FX, Wegrowski, Y	Exp. Cell Res.	2010