Reactome | LUM [extracellular region]

LUM [extracellular region]

Stable Identifier

R-HSA-2466189

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Lumican

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P51884 LUM

Gene Names

LUM, LDC, SLRR2D

Chain

signal peptide:1-18, chain:19-338

Reference Genes

BioGPS Gene:4060 LUM

COSMIC (genes):LUM LUM

CTD Gene:4060 LUM

dbSNP Gene:4060 LUM

ENSEMBL:ENSG00000139329.5 LUM

HGNC:6724 LUM

KEGG Gene (Homo sapiens):4060 LUM

Monarch:4060 LUM

NCBI Gene:4060 LUM

OMIM:600616 LUM

UCSC:P51884 LUM

Reference Transcript

RefSeq:NM_002345.3 LUM

Other Identifiers

0006650242

11715796_s_at

16768406

201744_PM_s_at

201744_s_at

229554_PM_at

229554_at

3465249

3465250

3465251

3465252

3465253

3465254

3465257

3465258

3465259

3465260

38038_at

4060

52570_at

7965403

A_23_P99063

A_24_P270279

GE79985

GE88676

GO:0003674

GO:0005198

GO:0005201

GO:0005515

GO:0005518

GO:0005575

GO:0005576

GO:0005583

GO:0005615

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0005794

GO:0005796

GO:0006351

GO:0006355

GO:0007601

GO:0008150

GO:0030021

GO:0030198

GO:0030199

GO:0030312

GO:0031012

GO:0032914

GO:0032991

GO:0043202

GO:0043226

GO:0045944

GO:0050877

GO:0062023

GO:0070062

HMNXSV003038106

Hs.79914.1.A1_3p_at

ILMN_1790529

ILMN_2167805

PH_hs_0024678

PH_hs_0040682

TC12001803.hg

U21128_at

g4505046_3p_a_at

Participates

as a candidate of

SLRPs [extracellular region] (Homo sapiens)

as a component of

LUM:Integrin alpha2beta1 [plasma membrane] (Homo sapiens)

as an input of

LUM (lumican) binds integrin alpha2beta1 (Homo sapiens)

Other forms of this molecule

KS(2)-LUM [extracellular region]

KS(2)-LUM [lysosomal lumen]

LUM [lysosomal lumen]

KS(1)-LUM [Golgi lumen]

KS(2)-LUM [Golgi lumen]

Keratan(4)-LUM [Golgi lumen]

Keratan(3)-LUM [Golgi lumen]

Keratan(2)-LUM [Golgi lumen]

Keratan(1)-LUM [Golgi lumen]

Gal-glycan LUM [Golgi lumen]

N-glycan LUM [Golgi lumen]

Inferred To

Dmel\CG32055 [extracellular region] (Drosophila melanogaster)

DS05899.7 [extracellular region] (Drosophila melanogaster)

lum [extracellular region] (Xenopus tropicalis)

Homologues of LUM [extracellular region] (Drosophila melanogaster)

LUM [extracellular region] (Bos taurus)

LUM [extracellular region] (Canis familiaris)

LUM [extracellular region] (Gallus gallus)

LUM [extracellular region] (Sus scrofa)

Lum [extracellular region] (Mus musculus)

Lum [extracellular region] (Rattus norvegicus)

zgc:86661 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_002336.1

OpenTargets

ENSG00000139329

GeneCards

P51884

HPA

ENSG00000139329-LUM

Ensembl

ENSG00000139329, ENST00000266718, ENSP00000266718

PRO

P51884

Pharos - Targets

P51884

Orphanet

28194

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P50281 MMP14	3	MMP14 [plasma membrane] (R-HSA-1442472) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724)	0.558	2
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3

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