Reactome | Nuclear CMP-Neu5Ac translocates to cytosol

Nuclear CMP-Neu5Ac translocates to cytosol

Stable Identifier

R-HSA-4084990

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
      - Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
        
        Sialic acid metabolism (Homo sapiens)
        
        Nuclear CMP-Neu5Ac translocates to cytosol (Homo sapiens)

General

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Nuclear CMP-Neu5Ac translocates to cytosol

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Once CMP-N-acetylneuraminate (CMP-Neu5Ac) is formed, it leaves the nucleus through nuclear pores to be further modified or used in conjugation reactions in the Golgi apparatus (Li & Chen 2012). The mechanism of translocation is unknown.

Literature References

PubMed ID	Title	Journal	Year
22526796	Sialic acid metabolism and sialyltransferases: natural functions and applications Li, Y, Chen, X	Appl. Microbiol. Biotechnol.	2012

Participants

Input

CMP-Neu5Ac [nucleoplasm]

Output

CMP-Neu5Ac [cytosol]

Participant Of

hasEvent

Sialic acid metabolism

Authored

Jassal, B (2013-08-01)

Reviewed

Medrano, JF (2014-01-08)

Wickramasinghe, S (2014-01-08)

Created

Jassal, B (2013-08-01)