Reactome | FBXL3 [nucleoplasm]

FBXL3 [nucleoplasm]

Stable Identifier

R-HSA-400380

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

F-box/LRR-repeat protein 3, FBXL3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UKT7 FBXL3

Gene Names

FBXL3, FBL3A, FBXL3A

Chain

chain:1-428

Reference Genes

BioGPS Gene:26224 FBXL3

COSMIC (genes):FBXL3 FBXL3

CTD Gene:26224 FBXL3

dbSNP Gene:26224 FBXL3

ENSEMBL:ENSG00000005812 FBXL3

HGNC:13599 FBXL3

KEGG:hsa:26224 FBXL3

Monarch:26224 FBXL3

NCBI Gene:26224 FBXL3

OMIM:605653 FBXL3

UCSC:Q9UKT7 FBXL3

Reference Transcript

Other Identifiers

11717982_a_at

11758250_s_at

16779844

225132_PM_at

225132_at

235608_PM_at

235608_at

26224

3518454

3518456

3518457

3518458

3518459

3518460

3518461

3518463

3518464

3518465

3518466

3518467

3518468

3518469

3518470

3518474

3518475

3518476

3518477

3518480

3518481

3518482

3518485

3518486

3518492

3518493

3518494

3518495

46854_at

54900_at

62716_at

78141_at

7972062

83645_at

GE54837

GE858911

GE860223

GO:0000151

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0016567

GO:0016604

GO:0016740

GO:0019005

GO:0030163

GO:0031146

GO:0031648

GO:0042752

GO:0043153

GO:0043161

GO:0043226

GO:0048511

GO:0140096

HMNXSV003039762

Hs.48614.0.A1_3p_at

Hs.7540.0.S1_3p_at

ILMN_2071405

TC13000742.hg

TC13000743.hg

Participates

as an output of

CRY proteins are ubiquitinylated (Homo sapiens)

as a component of

FBXL3:CRY [nucleoplasm] (Homo sapiens)

as an input of

FBXL3 binds phosphorylated CRY proteins (Homo sapiens)

Other forms of this molecule

FBXL3 [cytosol]

Cross References

RefSeq

NP_036290.1, XP_005266393.1

ENSEMBL

ENST00000355619, ENSP00000347834

OpenTargets

ENSG00000005812

HPA

ENSG00000005812-FBXL3

PRO

Q9UKT7

Pharos - Targets

Q9UKT7

PDB

4I6J

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9R194 Cry2	4	ub-p-Cry2 [nucleoplasm] (R-MMU-517964) p-Cry2 [nucleoplasm] (R-MMU-508638) p-Cry2 [cytosol] (R-MMU-508666) Cry2 [cytosol] (R-MMU-508614)	0.78	13
UniProt:Q16526 CRY1	4	Ub-p-S-CRY1 [nucleoplasm] (R-HSA-517931) CRY1 [cytosol] (R-HSA-400247) p-S-CRY1 [nucleoplasm] (R-HSA-400340) p-S-CRY1 [cytosol] (R-HSA-400270)	0.643	5
UniProt:Q9WTX5	2	Skp1 [nucleoplasm] (R-MMU-187538) Skp1 [cytosol] (R-MMU-174150)	0.623	4
UniProt:P97784 Cry1	4	ub-p-Cry1 [nucleoplasm] (R-MMU-517961) p-Cry1 [nucleoplasm] (R-MMU-508662) p-Cry1 [cytosol] (R-MMU-508644) Cry1 [cytosol] (R-MMU-508637)	0.564	2
UniProt:Q86XR8-3 CEP57			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9UJ68 MSRA	1	MSRA [cytosol] (R-HSA-5676904)	0.556	3
UniProt:P22670 RFX1			0.527	3
UniProt:P48378 RFX2			0.527	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.527	4
UniProt:P63209 SKP1			0.508	2

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