Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Skp1 [nucleoplasm]
Stable Identifier
R-MMU-9008726
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
S-phase kinase-associated protein 1, SKP1_MOUSE
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G1 Phase (Mus musculus)
Cyclin D associated events in G1 (Mus musculus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
G1/S Transition (Mus musculus)
Cyclin E associated events during G1/S transition (Mus musculus)
SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
Association of Cks1 with SCF(Skp2) complex (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
S Phase (Mus musculus)
Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
Association of Cks1 with SCF(Skp2) complex (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Cellular responses to external stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
Cytoprotection by HMOX1 (Mus musculus)
Regulation of HMOX1 expression and activity (Mus musculus)
Regulation of BACH1 activity (Mus musculus)
BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional regulation by RUNX2 (Mus musculus)
Regulation of RUNX2 expression and activity (Mus musculus)
SCF(SKP2) complex binds RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp1 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9WTX5 Skp1
Gene Names
Skp1, Skp1a
Chain
chain:1-163
Reference Genes
BioGPS Gene:21402 Skp1
ENSEMBL:ENSMUSG00000036309 Skp1
KEGG Gene (Mus musculus):21402 Skp1
Monarch:21402 Skp1
NCBI Gene:21402 Skp1
UCSC:Q9WTX5 Skp1
Reference Transcript
RefSeq:XM_006532786.2 Skp1
RefSeq:NM_011543.4 Skp1
Other Identifiers
10375935
1423148_at
1423149_at
17249425
21402
4382062
4517550
4568211
4710256
4969156
4989091
4992487
5077418
5093741
5161816
5378712
5381087
5406849
5441253
5496826
5573998
5595621
99607_at
A_52_P10458
A_55_P2156101
GE36447
GO:0006511
GO:0008150
GO:0009056
ILMN_2733888
Z47088_s_at
mMC006863
Participates
as a component of
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Fbxw7alpha:Skp1:Cul1:Rbx1 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Other forms of this molecule
Skp1 [cytosol]
Inferred From
SKP1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_006532849.1
,
NP_035673.3
Target Pathogen
5b354852be737e166372e948
Ensembl
ENSMUSP00000038744
,
ENSMUST00000109072
,
ENSMUSG00000036309
,
ENSMUSP00000104700
,
ENSMUST00000037324
PRO
Q9WTX5
MGI
103575
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UKT7 FBXL3
2
FBXL3 [cytosol]
(R-HSA-391289)
FBXL3 [nucleoplasm]
(R-HSA-400380)
0.623
4
UniProt:Q9CQJ4
1
Rnf2 [nucleoplasm]
(R-MMU-389119)
0.558
4
UniProt:Q9QXW2
1
Fbxw5 [cytosol]
(R-MMU-391286)
0.544
2
UniProt:P62137
1
Ppp1ca [cytosol]
(R-MMU-163525)
0.524
2
UniProt:Q83A11 Q83A11
0.488
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
