Gq alpha activates Phospholipase C beta

Stable Identifier
R-HSA-400023
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Gq alpha activates Phospholipase C beta
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The Gq alpha:GTP complex activates Phospholipase C beta-1 through protein interaction (inferred from homologues in Bos taurus). The activation by Gq alpha is insensitive to pertussis toxin whilst activation of PLC beta by the G beta-gamma complex is sensitive to pertussis toxin.
Literature References
PubMed ID Title Journal Year
1846707 Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

Smrcka, AV, Sternweis, PC, Hepler, JR, Brown, KO

Science 1991
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
Participants
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Output
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as an event of
Catalyst Activity

phospholipase activator activity of G-alpha(q) 11,14,15,Q:GTP [plasma membrane]

Physical Entity
G-alpha(q) 11,14,15,Q:GTP [plasma membrane] (Homo sapiens)
Activity
phospholipase activator activity (GO:0016004)
Inferred From
Activation of Phospholipase C beta1 by G(q)alpha:GTP (Mus musculus)
Authored
May, B  (2009-05-28)
Reviewed
D'Eustachio, P  (2024-01-29)
Gillespie, ME  (2009-06-02)
Created
May, B  (2009-03-24)
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