Gq alpha activates Phospholipase C beta

Stable Identifier
R-HSA-400023
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gq alpha activates Phospholipase C beta
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The Gq alpha:GTP complex activates Phospholipase C beta-1 through protein interaction (inferred from homologues in Bos taurus). The activation by Gq alpha is insensitive to pertussis toxin whilst activation of PLC beta by the G beta-gamma complex is sensitive to pertussis toxin.

Literature References
PubMed ID Title Journal Year
1846707 Regulation of polyphosphoinositide-specific phospholipase C activity by purified Gq

Smrcka, AV, Sternweis, PC, Hepler, JR, Brown, KO

Science 1991
17900700 G-protein-coupled receptors and islet function-implications for treatment of type 2 diabetes

Ahren, B, Winzell, MS

Pharmacol Ther 2007
11588141 Mechanisms and physiological significance of the cholinergic control of pancreatic beta-cell function

Gilon, P, Henquin, JC

Endocr Rev 2001
Participants
Input
Output
Participates
as an event of
Inferred From
Activation of Phospholipase C beta1 by G(q)alpha:GTP (Mus musculus)
Authored
May, B  (2009-05-28)
Reviewed
Gillespie, ME  (2009-06-02)
Created
May, B  (2009-03-24)
Cite Us!