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FARP2 [cytosol]
Stable Identifier
R-HSA-396935
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RhoGEF and pleckstrin domain-containing protein 2 (FARP2), FARP2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Semaphorin interactions (Homo sapiens)
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion (Homo sapiens)
Activation of Rac1 by FARP2 (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
FARP2:PIP5KIgamma [cytosol] (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
Plexin-A1-4 binds NRP1 (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
NRP1:PlexinA1-4:FARP2:FYN [plasma membrane] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
FARP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94887 FARP2
Gene Names
FARP2, KIAA0793, PLEKHC3
Chain
chain:1-1054
Reference Genes
BioGPS Gene:9855 FARP2
COSMIC (genes):FARP2 FARP2
CTD Gene:9855 FARP2
dbSNP Gene:9855 FARP2
ENSEMBL:ENSG00000006607 FARP2
HGNC:16460 FARP2
KEGG:hsa:9855 FARP2
Monarch:9855 FARP2
NCBI Gene:9855 FARP2
OMIM:617586 FARP2
UCSC:O94887 FARP2
Reference Transcript
RefSeq:NM_001282984.2 FARP2
RefSeq:NM_014808.4 FARP2
RefSeq:XM_047446510.1 FARP2
RefSeq:NM_001282983.2 FARP2
RefSeq:XM_054344762.1 FARP2
Other Identifiers
11743313_a_at
11749163_a_at
11760904_a_at
11760905_at
1554337_PM_at
1554337_at
16893482
204511_PM_at
204511_at
225652_PM_at
225652_at
242857_PM_at
242857_at
2536532
2536534
2536542
2536543
2536544
2536545
2536546
2536547
2536548
2536549
2536550
2536551
2536552
2536553
2536559
2536561
2536562
2536563
2536564
2536565
2536567
2536568
2536569
2536570
2536571
2536575
2536576
2536577
2536583
2536584
2536585
2536586
2536587
2536588
2536589
2536591
2536593
2536600
2536601
2536602
2536603
2536604
2536605
2536606
2536607
2536608
2536610
2536612
2536613
2536614
2536615
3316108
35188_at
3567745
3981510
4012453
63202_at
63327_at
79047_at
8049847
9855
A_14_P113440
A_14_P139315
A_23_P90855
A_24_P59485
A_24_P76759
A_33_P3350728
GE53493
GO:0005085
GO:0005737
GO:0005829
GO:0005856
GO:0007010
GO:0007155
GO:0008092
GO:0016322
GO:0016601
GO:0022405
GO:0030036
GO:0030154
GO:0030316
GO:0033623
GO:0043226
GO:0065003
GO:0071526
GO:0071800
GO:0098772
HMNXSV003014429
HMNXSV003047953
Hs.10490.0.A1_3p_at
Hs.311977.0.S1_3p_at
Hs2.301283.2.S1_3p_s_at
ILMN_2062687
PH_hs_0015530
TC02001478.hg
TC02001479.hg
TC02003940.hg
g7662309_3p_at
Participates
as a candidate of
RAC1 GEFs [cytosol] (Homo sapiens)
as a component of
FARP2:PIP5KIgamma [cytosol] (Homo sapiens)
Plexin-A1-4:FYN:FARP2 [plasma membrane] (Homo sapiens)
as an input of
Inhibition of integrin activation by sequestering PIP5KIgamma (Homo sapiens)
Plexin-A1-4 binds NRP1 (Homo sapiens)
as an output of
Sema3A binds Nrp-1 bound to PlexinA (Homo sapiens)
Inferred To
FARP2 [cytosol]
(Bos taurus)
FARP2 [cytosol]
(Canis familiaris)
FARP2 [cytosol]
(Gallus gallus)
FARP2 [cytosol]
(Sus scrofa)
Farp2 [cytosol]
(Mus musculus)
Farp2 [cytosol]
(Rattus norvegicus)
Ghost homologue of FARP2 [cytosol]
(Danio rerio)
Ghost homologue of FARP2 [cytosol]
(Xenopus tropicalis)
Cdep [cytosol]
(Drosophila melanogaster)
frm-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_047302466.1
,
NP_001269913.1
,
NP_001269912.1
,
XP_054200737.1
,
NP_055623.1
ENSEMBL
ENST00000627550
,
ENSP00000264042
,
ENSG00000006607
,
ENST00000264042
,
ENSP00000486597
,
ENST00000373287
,
ENSP00000362384
OpenTargets
ENSG00000006607
GeneCards
FARP2
HPA
ENSG00000006607-FARP2
PRO
O94887
Pharos - Targets
O94887
HMDB Protein
HMDBP11476
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P54105 CLNS1A
1
CLNS1A [cytosol]
(R-HSA-191796)
0.527
2
UniProt:Q15287 RNPS1
2
RNPS1 [cytosol]
(R-HSA-159256)
RNPS1 [nucleoplasm]
(R-HSA-156778)
0.527
2
UniProt:Q9Y6H6 KCNE3
1
KCNE3 [plasma membrane]
(R-HSA-977536)
0.527
3
UniProt:P12273 PIP
1
PIP [extracellular region]
(R-HSA-5252061)
0.527
2
UniProt:P49674 CSNK1E
2
CSNK1E [cytosol]
(R-HSA-205877)
CSNK1E [nucleoplasm]
(R-HSA-421306)
0.527
2
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