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TBXA2R [plasma membrane]
Stable Identifier
R-HSA-391837
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TP receptor, RecName: Full=Thromboxane A2 receptor; Short=TXA2-R; AltName: Full=Prostanoid TP receptor;
GN Name=TBXA2R;
OS Homo sapiens, TA2R_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
Thromboxane signalling through TP receptor (Homo sapiens)
Activated TP receptor binds G-protein G13 (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Activated TP receptor binds G-proten Gq (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Dissociation of the TP:G13 complex (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Dissociation of the TP:Gq complex (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
G13 activation by TP receptor (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Gq activation by TP receptor (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TP receptor can bind thromboxane (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
GPCRs that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
TP receptor can bind thromboxane (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TBXA2R [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21731 TBXA2R
Gene Names
TBXA2R
Chain
chain:1-343
Reference Genes
BioGPS Gene:6915 Q0VAB0
COSMIC (genes):TBXA2R TBXA2R
CTD Gene:6915 Q0VAB0
dbSNP Gene:6915 Q0VAB0
ENSEMBL:ENSG00000006638 TBXA2R
HGNC:11608 TBXA2R
KEGG:hsa:6915 Q0VAB0
Monarch:6915 Q0VAB0
NCBI Gene:6915 Q0VAB0
OMIM:188070 TBXA2R
UCSC:P21731 TBXA2R
Reference Transcript
RefSeq:NM_201636.2 Q0VAB0
RefSeq:NM_001060.5 Q0VAB0
RefSeq:XM_011528214.2 TBXA2R
Participates
as an output of
Dissociation of the TP:Gq complex (Homo sapiens)
Dissociation of the TP:G13 complex (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
GPCRs that activate G12/13 [plasma membrane] (Homo sapiens)
as an input of
TP receptor can bind thromboxane (Homo sapiens)
as a component of
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Inferred To
Tbxa2r [plasma membrane]
(Mus musculus)
Tbxa2r [plasma membrane]
(Rattus norvegicus)
BcDNA:GH27361 [plasma membrane]
(Drosophila melanogaster)
TBXA2R [plasma membrane]
(Bos taurus)
TBXA2R [plasma membrane]
(Canis familiaris)
TBXA2R [plasma membrane]
(Gallus gallus)
TBXA2R [plasma membrane]
(Sus scrofa)
Ghost homologue of TBXA2R [plasma membrane]
(Caenorhabditis elegans)
tbxa2r [plasma membrane]
(Danio rerio)
tbxa2r [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001051.1
,
NP_963998.2
,
XP_011526516.1
Guide to Pharmacology - Targets
346
ENSEMBL
ENSG00000006638
,
ENST00000375190
,
ENSP00000364336
,
ENSP00000393333
,
ENST00000411851
OpenTargets
ENSG00000006638
ZINC - Substances
TA2R_HUMAN
ZINC - Biogenic
TA2R_HUMAN
ZINC target
P21731
PRO
P21731
GlyGen
P21731
PDB
8XJO
,
8XJN
ZINC - Investigational
TA2R_HUMAN
GeneCards
TBXA2R
HPA
ENSG00000006638-TBXA2R
Pharos - Targets
P21731
Orphanet
TBXA2R
ZINC - Predictions - Purchasable
TA2R_HUMAN
HMDB Protein
HMDBP02023
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13162 PRDX4
3
PRDX4 [secretory granule lumen]
(R-HSA-6803305)
PRDX4 [extracellular region]
(R-HSA-6806512)
PRDX4 [ficolin-1-rich granule lumen]
(R-HSA-6803286)
0.593
3
UniProt:P0DTD8 NS7B
0.488
2
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