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TBXA2R:TXA2 [plasma membrane]
Stable Identifier
R-HSA-391925
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TP receptor:Thromboxane A2
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
Thromboxane signalling through TP receptor (Homo sapiens)
Activated TP receptor binds G-protein G13 (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Activated TP receptor binds G-proten Gq (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Dissociation of the TP:G13 complex (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Dissociation of the TP:Gq complex (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
G13 activation by TP receptor (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Gq activation by TP receptor (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
TP receptor can bind thromboxane (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Eicosanoid ligand-binding receptors (Homo sapiens)
Prostanoid ligand receptors (Homo sapiens)
TP receptor can bind thromboxane (Homo sapiens)
TBXA2R:TXA2 [plasma membrane] (Homo sapiens)
Participants
components
TBXA2R [plasma membrane]
(Homo sapiens)
TXA2 [extracellular region]
Participates
as a component of
TP receptor:Thromboxane A2:G-protein Gq (active) [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
as an input of
Activated TP receptor binds G-proten Gq (Homo sapiens)
Activated TP receptor binds G-protein G13 (Homo sapiens)
as a member of
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13 [plasma membrane] (Homo sapiens)
as an output of
TP receptor can bind thromboxane (Homo sapiens)
Inferred To
TBXA2R:TXA2 [plasma membrane]
(Bos taurus)
TBXA2R:TXA2 [plasma membrane]
(Caenorhabditis elegans)
TBXA2R:TXA2 [plasma membrane]
(Canis familiaris)
TBXA2R:TXA2 [plasma membrane]
(Danio rerio)
TBXA2R:TXA2 [plasma membrane]
(Drosophila melanogaster)
TBXA2R:TXA2 [plasma membrane]
(Gallus gallus)
TBXA2R:TXA2 [plasma membrane]
(Mus musculus)
TBXA2R:TXA2 [plasma membrane]
(Rattus norvegicus)
TBXA2R:TXA2 [plasma membrane]
(Sus scrofa)
TBXA2R:TXA2 [plasma membrane]
(Xenopus tropicalis)
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