Reactome | Follicle-stimulating hormone receptor can bind FSH

Follicle-stimulating hormone receptor can bind FSH

Stable Identifier

R-HSA-391378

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Follicle-stimulating hormone receptor can bind FSH

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Follicle-stimulating hormone (FSH) is a dimeric glycoprotein hormone synthesized and secreted by gonadotropes in the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the human body. The actions of FSH are mediated by the FSH receptor (Minegishi T et al, 1991), found in the ovaries, testes and uterus.
Once activated, the receptor mediates its action by coupling to the G protein alpha-s subunit (Timossi C et al, 2002), which activates adenylate cyclase and increases intracellular cAMP levels.

Literature References

PubMed ID	Title	Journal	Year
1709010	Cloning and sequencing of human FSH receptor cDNA Minegishi, T, Nakamura, K, Takakura, Y, Ibuki, Y, Igarashi, M, Minegish T [corrected to Minegishi, T	Biochem Biophys Res Commun	1991
12039074	Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation Timossi, C, Maldonado, D, Vizcaino, A, Lindau-Shepard, B, Conn, PM, Ulloa-Aguirre, A	Mol Cell Endocrinol	2002