Follicle-stimulating hormone receptor can bind FSH

Stable Identifier
R-HSA-391378
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Follicle-stimulating hormone (FSH) is a dimeric glycoprotein hormone synthesized and secreted by gonadotropes in the anterior pituitary gland. FSH regulates the development, growth, pubertal maturation, and reproductive processes of the human body. The actions of FSH are mediated by the FSH receptor (Minegishi T et al, 1991), found in the ovaries, testes and uterus.
Once activated, the receptor mediates its action by coupling to the G protein alpha-s subunit (Timossi C et al, 2002), which activates adenylate cyclase and increases intracellular cAMP levels.

Literature References
PubMed ID Title Journal Year
12039074 Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation

Timossi, C, Maldonado, D, Vizcaino, A, Lindau-Shepard, B, Conn, PM, Ulloa-Aguirre, A

Mol Cell Endocrinol 2002
1709010 Cloning and sequencing of human FSH receptor cDNA

Minegishi, T, Nakamura, K, Takakura, Y, Ibuki, Y, Igarashi, M, Minegish T [corrected to Minegishi, T

Biochem Biophys Res Commun 1991
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