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ADRA2C [plasma membrane]
Stable Identifier
R-HSA-390662
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Alpha-2C adrenoceptor, RecName: Full=Alpha-2C adrenergic receptor; AltName: Full=Alpha-2C adrenoreceptor; AltName: Full=Alpha-2C adrenoceptor; AltName: Full=Alpha-2 adrenergic receptor subtype C4;
GN Name=ADRA2C; Synonyms=ADRA2L2, ADRA2RL2;
OS Homo sapiens, ADA2C_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Adrenaline signalling through Alpha-2 adrenergic receptor (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
Adrenaline,noradrenaline inhibits insulin secretion (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Alpha-2A,alpha-2C Adrenergic Receptors bind adrenaline or noradrenaline (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Surfactant metabolism (Homo sapiens)
SFTPB,C, PC, PG translocate from lamellar body to extracellular region (Homo sapiens)
ADRA2A,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
G alpha (z) signalling events (Homo sapiens)
Liganded Gz-activating GPCR acts as a GEF for Gz (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Liganded Gz-activating GPCRs bind inactive heterotrimeric G-protein Gz (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gz:Heterotrimeric G-protein Gz (inactive) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gz complex dissociates (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A-C:Catecholamine:Heterotrimeric G-protein Gz (active) [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Amine ligand-binding receptors (Homo sapiens)
Adrenoceptors (Homo sapiens)
ADRA2A,B,C bind ADR,NAd (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
ADRA2A,B,C:ADR,NAd [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
α2-agonists bind ADRA2A,B,C (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
α2-agonists:ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
ADRA2C [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18825 ADRA2C
Gene Names
ADRA2C, ADRA2L2, ADRA2RL2
Chain
chain:1-462
Reference Genes
BioGPS Gene:152 ADRA2C
COSMIC - genes:ADRA2C ADRA2C
CTD Gene:152 ADRA2C
dbSNP Gene:152 ADRA2C
ENSEMBL:ENSG00000184160 ADRA2C
HGNC:283 ADRA2C
KEGG:hsa:152 ADRA2C
Monarch:152 ADRA2C
NCBI Gene:152 ADRA2C
OMIM:104250 ADRA2C
UCSC:P18825 ADRA2C
Reference Transcript
RefSeq:NM_000683.4 ADRA2C
Other Identifiers
11728580_x_at
11756359_s_at
152
16964516
206128_PM_at
206128_at
2716330
2716331
2716332
2716333
2716334
2716335
2716336
2716337
2716338
2716339
2716340
2716341
34512_at
8093826
A_14_P111386
A_23_P256158
GE57492
GO:0003013
GO:0004930
GO:0004935
GO:0004938
GO:0005085
GO:0005515
GO:0005737
GO:0005768
GO:0005886
GO:0006940
GO:0007165
GO:0007173
GO:0007186
GO:0007267
GO:0010700
GO:0016020
GO:0019229
GO:0030168
GO:0031694
GO:0032811
GO:0042803
GO:0043410
GO:0045666
GO:0046676
GO:0046982
GO:0051379
GO:0051897
GO:0071875
HMNXSV003015120
Hs.123022.0.S2_3p_at
ILMN_1733963
PH_hs_0027798
TC04000052.hg
U72648_s_at
Participates
as a member of
ADRA2A,C [plasma membrane] (Homo sapiens)
ADRA2A,B,C [plasma membrane] (Homo sapiens)
Inferred To
Oct-TyrR [plasma membrane]
(Drosophila melanogaster)
ADRA2C [plasma membrane]
(Bos taurus)
ADRA2C [plasma membrane]
(Canis familiaris)
ADRA2C [plasma membrane]
(Gallus gallus)
ADRA2C [plasma membrane]
(Sus scrofa)
ser-2 [plasma membrane]
(Caenorhabditis elegans)
adra2c [plasma membrane]
(Danio rerio)
adra2c [plasma membrane]
(Xenopus tropicalis)
Adra2c [plasma membrane]
(Mus musculus)
Adra2c [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000674.2
ZINC - World Drugs
ADA2C_HUMAN
Guide to Pharmacology - Targets
27
ENSEMBL
ENSG00000184160
,
ENSP00000386069
,
ENST00000330055
OpenTargets
ENSG00000184160
ZINC - FDA approved
ADA2C_HUMAN
ZINC - Substances
ADA2C_HUMAN
ZINC - Biogenic
ADA2C_HUMAN
ZINC target
P18825
PRO
P18825
GlyGen
P18825
PDB
6KUW
ZINC - Investigational
ADA2C_HUMAN
ZINC - Metabolites
ADA2C_HUMAN
GeneCards
ADRA2C
HPA
ENSG00000184160-ADRA2C
Pharos - Targets
P18825
ZINC - Predictions - Purchasable
ADA2C_HUMAN
HMDB Protein
HMDBP10771
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
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