Reactome | TNNI3 [cytosol]

TNNI3 [cytosol]

Stable Identifier

R-HSA-390542

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Troponin I, cardiac muscle, TNNI3_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Cardiac conduction (Homo sapiens)
  - Ion homeostasis (Homo sapiens)
    - PRKACA phosphorylates TNNI3 (Homo sapiens)
      - TNNI3 [cytosol] (Homo sapiens)
- Striated Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
  - Calcium Binds Troponin-C (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
    - Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament [cytosol] (Homo sapiens)
        
        Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)
    - Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
      - Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
        
        Calcium:Troponin Complex [cytosol] (Homo sapiens)
        
        Troponin I [cytosol] (Homo sapiens)
        
        TNNI3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P19429 TNNI3

Gene Names

TNNI3, TNNC1

Chain

initiator methionine:1, chain:2-210

Reference Genes

BioGPS Gene:7137 TNNI3

COSMIC (genes):TNNI3 TNNI3

CTD Gene:7137 TNNI3

dbSNP Gene:7137 TNNI3

ENSEMBL:ENSG00000129991 TNNI3

ENSEMBL:ENSG00000129991.13 TNNI3

HGNC:11947 TNNI3

KEGG Gene (Homo sapiens):7137 TNNI3

Monarch:7137 TNNI3

NCBI Gene:7137 TNNI3

OMIM:191044 TNNI3

Reference Transcript

RefSeq:NM_000363.4 TNNI3

Other Identifiers

11722648_a_at

16875612

205742_PM_at

205742_at

36477_at

3871128

3871129

3871130

3871131

3871134

3871135

3871137

3871139

3871140

3871141

7137

8039353

A_23_P67453

GE80910

GE87542

GO:0001570

GO:0001980

GO:0003009

GO:0003012

GO:0003013

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005861

GO:0006874

GO:0006937

GO:0006940

GO:0006941

GO:0007507

GO:0008092

GO:0010882

GO:0019855

GO:0019901

GO:0019904

GO:0023052

GO:0030016

GO:0030017

GO:0030154

GO:0030172

GO:0031014

GO:0032780

GO:0043226

GO:0043292

GO:0048306

GO:0048856

GO:0050877

GO:0051015

GO:0055010

GO:0055065

GO:0060047

GO:0060048

GO:0097512

GO:0098772

GO:0140678

GO:1990584

HMNXSV003011601

PH_hs_0028634

PH_hs_0034354

TC19001859.hg

X90780_rna1_at

g4507622_3p_at

Participates

as a member of

Troponin I [cytosol] (Homo sapiens)

as an input of

PRKACA phosphorylates TNNI3 (Homo sapiens)

Other forms of this molecule

p-S23,S24-TNNI3 [cytosol]

Inferred To

unc-27 [cytosol] (Caenorhabditis elegans)

tni-3 [cytosol] (Caenorhabditis elegans)

Tnni3 [cytosol] (Mus musculus)

Tnni3 [cytosol] (Rattus norvegicus)

zgc:92191 [cytosol] (Danio rerio)

zgc:92053 [cytosol] (Danio rerio)

tnni3 [cytosol] (Xenopus tropicalis)

zgc:110715 [cytosol] (Danio rerio)

tni-1 [cytosol] (Caenorhabditis elegans)

zgc:103650 [cytosol] (Danio rerio)

TNNI3 [cytosol] (Canis familiaris)

TNNI3 [cytosol] (Danio rerio)

TNNI3 [cytosol] (Sus scrofa)

wupA [cytosol] (Drosophila melanogaster)

Homologues of TNNI3 [cytosol] (Caenorhabditis elegans)

Homologues of TNNI3 [cytosol] (Danio rerio)

tni-4 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_000354.4

OpenTargets

ENSG00000129991

HPA

ENSG00000129991-TNNI3

GeneCards

P19429

Ensembl

ENSG00000129991, ENST00000344887, ENSP00000341838

PRO

P19429

Pharos - Targets

P19429

Orphanet

15638

HMDB Protein

HMDBP08061

PDB

7UTL, 7SXD, 7JGI, 7SVC, 7SWI, 7UTI, 7SXC, 2KGB, 1OZS, 7SWG, 2MZP, 4Y99, 1MXL, 2L1R, 6MV3, 6KN7, 7UHA, 2N7L, 7SUP, 6KN8, 7UH9, 1J1D, 7SC2, 1J1E, 5WCL, 2KRD, 7SC3, 1LXF, 5W88, 5VLN

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P02585 TNNC2	1	TNNC2 [cytosol] (R-HSA-390531)	0.556	3
UniProt:O43933 PEX1	1	PEX1 [cytosol] (R-HSA-9033116)	0.556	3
UniProt:A6NK89 RASFA			0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P63316 TNNC1	1	TNNC1 [cytosol] (R-HSA-390533)	0.536	4
UniProt:Q9UKA8-4 RCAN3			0.527	2
UniProt:Q9UKA8-1 RCAN3			0.527	3
UniProt:Q59H18 TNI3K			0.508	2