acetyl-CoA + H2O => acetate + CoASH + H+

Stable Identifier
R-HSA-390304
Type
Reaction [transition]
Species
Homo sapiens
Compartment
peroxisomal matrix
Synonyms
acetyl-CoA + H2O => acetate + CoA + H(+)
ReviewStatus
5/5
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acetyl-CoA + H2O => acetate + CoASH + H+
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Peroxisomal ACOT8 catalyzes the hydrolysis of acetyl-CoA to form acetate and CoASH (Jones et al. 1999; Wanders and Waterham 2006).
Literature References
PubMed ID Title Journal Year
16756494 Biochemistry of mammalian peroxisomes revisited

Wanders, RJA, Waterham, HR

Annu Rev Biochem 2006
10092594 Identification of peroxisomal acyl-CoA thioesterases in yeast and humans

Jones, JM, Geraghty, MT, Erdmann, R, Gould, SJ, Nau, K

J Biol Chem 1999
Participants
Input
Output
Participates
as an event of
Catalyst Activity

acetyl-CoA hydrolase activity of ACOT8 [peroxisomal matrix]

Physical Entity
ACOT8 [peroxisomal matrix] (Homo sapiens)
Activity
acetyl-CoA hydrolase activity (GO:0003986)
Orthologous Events
acetyl-CoA + H2O => acetate + CoASH + H+ (Bos taurus)
acetyl-CoA + H2O => acetate + CoASH + H+ (Caenorhabditis elegans)
acetyl-CoA + H2O => acetate + CoASH + H+ (Canis familiaris)
acetyl-CoA + H2O => acetate + CoASH + H+ (Danio rerio)
acetyl-CoA + H2O => acetate + CoASH + H+ (Gallus gallus)
acetyl-CoA + H2O => acetate + CoASH + H+ (Mus musculus)
acetyl-CoA + H2O => acetate + CoASH + H+ (Rattus norvegicus)
acetyl-CoA + H2O => acetate + CoASH + H+ (Saccharomyces cerevisiae)
acetyl-CoA + H2O => acetate + CoASH + H+ (Sus scrofa)
acetyl-CoA + H2O => acetate + CoASH + H+ (Xenopus tropicalis)
Cross References
RHEA
Rhea
Authored
D'Eustachio, P  (2009-03-16)
Reviewed
Jassal, B  (2009-02-27)
Hill, DP  (2024-08-02)
Created
D'Eustachio, P  (2009-01-25)
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