Reactome | acetyl-CoA + carnitine => acetylcarnitine + CoASH

acetyl-CoA + carnitine => acetylcarnitine + CoASH

Stable Identifier

R-HSA-390291

Type

Reaction [transition]

Species

Homo sapiens

Compartment

peroxisomal matrix

Synonyms

R)-carnitine + acetyl-CoA => CoA + O-acetyl-(R)-carnitine

ReviewStatus

5/5

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acetyl-CoA + carnitine => acetylcarnitine + CoASH

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Peroxisomal carnitineacetyltransferase (CRAT) catalyzes the reaction of acetyl-CoA and carnitine to form acetylcarnitine and CoASH. The active form of the enzyme is a monomer (Bloisi et al. 1990; Govindasamy et al. 2004; Wu et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12562770	Structure of human carnitine acetyltransferase. Molecular basis for fatty acyl transfer. Wu, D, Govindasamy, L, Lian, W, Gu, Y, Kukar, T, Agbandje-McKenna, M, McKenna, R	J Biol Chem	2003
2351134	Purification and properties of carnitine acetyltransferase from human liver Bloisi, W, Colombo, I, Garavaglia, B, Giardini, R, Finocchiaro, G, DiDonato, S	Eur J Biochem	1990
15099582	Structural and mutational characterization of L-carnitine binding to human carnitine acetyltransferase Govindasamy, L, Kukar, T, Lian, W, Pedersen, B, Gu, Y, Agbandje-McKenna, M, Jin, S, McKenna, R, Wu, D	J Struct Biol	2004